摘要
目的探讨肺炎支原体感染患儿血浆D-二聚体含量在肺炎支原体感染过程中的变化及临床意义。方法将来自深圳市宝安妇幼保健院2012年7月至2014年3月住院期间的176例肺炎支原体感染患儿依其病程分为感染组(176例)和治愈组(60例),同时选取70例正常儿童作为对照组,分别测定其血浆D-二聚体及血清肺炎支原体抗体,并对其进行比较分析。结果肺炎支原体感染组患儿血浆D-二聚体水平较治愈组和对照组显著升高(t值分别为4.33和5.11,均P<0.05)、肺炎支原体感染期间(肺炎支原体抗体滴度水平在1:320及以上者53例,滴度在1:160者65例,滴度1:80的58例)不同抗体水平的患儿血浆D-二聚体水平均无明显差异(t值分别为0.64、0.48和1.40,均P>0.05)。结论肺炎支原体感染患儿体内存在着凝血、纤溶活性的异常,D-二聚体水平在感染期明显升高。
Objective To investigate the changes in infection period and significance of plasma D-dimer levels in mycoplasma pneumoniae infected children.Methods From July 2012 to March 2014 plasma D-dimer and mycoplasma pneumoniae antibodies in serum of 176 cases of mycoplasma pneumonia in infection group admitted in Maternal and Child Health Care Hospital of Baoan District, cure group (n=60) and control group ( n=70) were measured, and comparison analysis was conducted.Results Mycoplasma pneumoniae infection group has significantly higher level of plasma D-dimer than the cure group and the control group (t value was 4.33 and 5.11, respectively, both P〈0.05).During the mycoplasma pneumoniae infection period there was no significant difference in D-dimer level among cases with different antibody levels (53 cases with titer of 1:320 or more, 65 cases with titer of 1:160, 58 cases with titer of 1:80) (t value was 0.64, 0.48 and 1.40, respectively, all P 〉0.05).Conclusion In vivo coagulation and fibrinolytic activity abnormalities exist in children with mycoplasma pneumoniae infection, and their D-dimer levels elevate significantly in infection period.
出处
《中国妇幼健康研究》
2015年第2期357-359,共3页
Chinese Journal of Woman and Child Health Research
关键词
肺炎支原体
血浆D-二聚体
肺炎支原体抗体
儿童
mycoplasma pneumoniae (MP)
plasma D-dimer
mycoplasma pneumoniae antibody
children