摘要
目的探讨D-二聚体(D-D)和C-反应蛋白(CRP)在肺炎、肺结核(TB)、潜伏性结核感染(LTI)、重症肺结核、肺癌患者及健康人群中的水平差异及临床意义。方法比较44例肺炎患者、41例肺结核、30例潜伏性结核感染、27例重症肺结核、42例肺癌患者和健康对照组49名的D-D及CRP含量,并进行相关分析。结果血浆D-D含量水平:重症肺结核组最高,为(0.577±0.488)mg/L,肺癌、肺结核及肺炎次之,分别为(0.338±0.326)、(0.324±0.278)、(0.320±0.233)mg/L,潜伏性结核感染与健康对照组含量最低,为(0.283±0.262)、(0.180±0.154)mg/L;血清CRP水平:重症肺结核组及肺炎最高,为(108.67±68.94)、(75.91±77.83)mg/L,肺结核及肺癌次之,分别为(53.42±58.91)、(39.61±43.80)mg/L,潜伏性结核感染与健康对照组含量最低,为(25.03±21.42)、(13.03±9.69)mg/L;血浆D-D与血清CRP含量变化存在相关性,肺炎组r=0.463,肺结核组r=0.325,重症肺结核组r=0.178,健康对照组r=0.143,肺癌组r=0.121,潜伏性结核感染组r=0.076,均P<0.05;肺癌死亡组第1天及观察终点D-D、CRP水平均高于正常组。结论 D-D及CRP水平与疾病严重程度及感染相关炎症分级密切相关,可作为判断病情及评估预后的指标。
OBJECTIVE To explore the clinical significance and compare the difference of D-dimer（D-D） and C-reactive protein（CRP） levels in patients with pulmonary infections,active pulmonary tuberculosis（TB）,latent tuberculosis infection（LTI）,severe pulmonary tuberculosis,lung cancer and healthy subjects.METHODS Our study was designed to evaluate D-D,and CRP levels in 44 pneumonia cases,41 active pulmonary tuberculosis（TB） cases,30 LTI cases,27 severe pulmonary tuberculosis cases,42 lung cancer cases and 49 healthy subjects,then the correlation was statistically analyzed.RESULTS D-D levels was found to be the highest in the cases with severe pulmonary tuberculosis（0.577±0.488 mg/L）,followed by the lung cancer,active pulmonary tuberculosis and pulmonary infection（0.338±0.326 mg/L,0.324±0.278 mg/L and 0.320±0.233 mg/L）,and latent tuberculosis infection and healthy people（0.283±0.262 mg/L and 0.180±0.154 mg/L）;CRP levels was found to be significantly higher in cases with severe pulmonary tuberculosis and pulmonary infection（108.67±68.94 mg/L and 75.91±77.83 mg/L）,followed by the pulmonary tuberculosis and the lug cancer（53.42±58.91）,（39.61±43.80）mg/L,the latent tuberculosis infection and healthy people（25.03±21.42 mg/L and 13.03±9.69 mg/L） were the lowest;there was a correlation between the level of D-D and level of CRP,r=0.463 of the pulmonary infection group,r=0.325 of active pulmonary tuberculosis group,r=0.178 of severe pulmonary tuberculosis,r=0.143 of healthy people group,r=0.121 of lung cancer group,and r=0.076 of latent tuberculosis infection group（P0.05）.both of the D-D and CRP levels of the lung caner group were higher than the control group on the first and final of the observation.CONCLUSION The increasing of D-D and CRP levels are found to be correlated with the severity of the diseases and the infections,which can serve as indicators for the condition judgment and the evaluation of prognosis.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第4期787-789,共3页
Chinese Journal of Nosocomiology
关键词
D-二聚体
C-反应蛋白
肺炎
肺结核
潜伏性结核
重症肺结核
肺癌
D-dimer
C-reactive protein
Pulmonary infection
Pulmonary tuberculosis
Latent tuberculosis
Severe pulmonary tuberculosis
Lung cancer
