摘要
目的探讨胸膜外孤立性纤维性肿瘤(SFT)的临床病理学特征、诊断及鉴别诊断。方法回顾性复习10例SFT、2例肌周细胞瘤、2例脑膜血管外周细胞瘤的临床及病理学表现,并复习相关文献。结果 10例SFT中,8例为良性,1例为恶性,1例为低度恶性潜能。巨检均表现为局限性包块,2例边界不清。镜检肿瘤组织密集区与疏松区交替,其间有胶原纤维分割;肿瘤细胞呈梭形、短梭形和圆形,呈编织状、条索状或血管外皮瘤样排列;恶性肿瘤呈浸润性生长,细胞致密,细胞有异型性,核分裂象≥4/10HPF,可见坏死;低度恶性潜能者核分裂象少于3/10HPF。免疫组化染色显示,SFT组织vim、CD34、CD99、bcl-2阳性分别为10、9、8、7例。结论 SFT是一种少见的间叶组织来源肿瘤,大多为良性,少数为恶性,确诊主要依靠病理形态学及免疫组织化学染色结果。
Objective To study the clinicopathologic features,diagnosis and differential diagnosis of extrapleural solitary fibrous tumors（SFT）. Methods The clinical and pathologic manifestations of 10 cases of SFT,two cases of myopericytoma（MPC）,and two cases of meningeal haemangiopericytoma（M-HPC）were retrospectively analyzed and the related literature was reviewed. Results Of the 10 cases of SFT,eight were malignant,one was benign,and one was low malignant potential.Gross examination all showed localized mass,of which,two with obscure boundary.Microscopically,hypercellularity and hypocellularity was interchanged,with collagen fiber in between.The tumor cells were spindle-shaped,short-spindle shaped or round,and arranged like fascicular or storiform pattem or hemangiopericytoma-like structure.The malignant cells showed infiltrative growth,hypercellularity,and nuclear atypia,with a mitotic count greater than 4/10 HPF,and necrosis could be seen.The mitotic count was less than 3/10 HPF in the tumors with low-malignant potential.The immunohistochemical study showed that positive for vim,CD34,CD99 and bcl-2in SFT tissue was 10/10,9/10,8/10,and 7/10,respectively. Conclusion Solitary fibrous tumors are rare,which arise from mesenchymal tissues,most are benign,but a few can be malignant.Their diagnosis mainly based on pathomorphism and immunohistochemical staining.
出处
《齐鲁医学杂志》
2015年第2期132-134,共3页
Medical Journal of Qilu
关键词
组织细胞瘤
良性纤维性
诊断
鉴别
免疫组织化学
histiocytoma, benign fibrous
diagnosis, differential
immunohistochemistry
