摘要
目的探讨乳腺浸润性导管癌组织常规免疫组化标记表达的异质性。方法对1例非特殊型乳腺浸润性导管癌进行分析,观察其组织学异质性和常规免疫组化标记阳性表达的特征,并复习相关文献。结果该病例镜下组织特征基本表现为3种不同分化区域,且3种区域在免疫组化表型上存在明显差异。免疫组化:ER(80%)和PR<1%(+),Her-2(2+),Ki-67阳性指数20%,p53(2%)(+)。结论乳腺癌是一种具有高度异质性的肿瘤,其异质性表现在很多方面。个体化诊治对临床治疗方案的选择和预后预测起着至关重要的作用。
Objective To investigate the expression heterogeneity of routine immunohistochemical markers in breast invasive ductal carcinoma. Methods One case of non-specific invasive ductal carcinoma was studied with histology and expression characteristics of routine immunohistochemical markers, followed by review of literature to investigate the heterogeneity of breast cancer. Results Three differentiation areas were observed under the microscope. There were obvious immunohistochemical phenotype differences in three areas. Pathological diagnosis of this ease was invasive duetal carcinoma, non-specific, histological grade Ⅱ. Immunohistoehemical results （ the whole slice） showed that tumor cells were ER＋ （80%）, PR＋（〈1%）, Her-2 （2＋）, Ki-67 ＋ （20%）, and p53 ＋ （2%）. Conclusion Breast cancer is a highly heterogeneous tumor in many aspects. Breast cancer diagnosis plays a vital role for clinical treatment options and prognosis evaluation in the individualized diagnosis and treatment.
出处
《诊断病理学杂志》
CSCD
2015年第4期241-243,共3页
Chinese Journal of Diagnostic Pathology
关键词
乳腺癌
肿瘤异质性
免疫组化
Breast cancer
Tumor heterogeneity
Immunohistochemistry
