摘要
目的探讨CUEDC2在卵巢浆液性癌中的表达特点及其与临床病理参数及预后的关系。方法对47例卵巢浆液性癌手术切除标本,采用两级病理分级系统判定组织学分级;采用免疫组化En Vision二步法检测癌组织中CUEDC2表达,结合病例随访结果分析CUEDC2与卵巢浆液性癌发生、发展的关系。结果 147例卵巢浆液性癌病例中,28例CUEDC2呈(+),阳性率为59.6%。2CUEDC2在高级别(HG)组中阳性率(66.7%)明显高于低级别(LG)组(25%),差异显著(P<0.05);CUEDC2表达与年龄、FIGO分期及淋巴结有/无转移无相关性(P>0.05)。3CUEDC2阳性组的肿瘤复发率及死亡率均高于CUEDC2阴性组,但单因素生存分析显示两组患者无瘤生存时间及总生存时间无显著差异(P>0.05)。结论卵巢浆液性癌的病理级别越高,CUEDC2的阳性率越高,CUEDC2阳性可作为预后不良的预测因子。
Objective To investigate the expression CUEDC2 in ovarian serous carcinoma tissues, and its clinieopathologieal value. Methods Archival paraffin-embedded tissue blocks from 47 patients with serous carcinoma of ovary were obtained from the People＇ s Liberation Army General Hospital between January 2007 and December 2010. The tumors were graded using a two-tier system. The expression of CUEDC2 was detected by using immunohistochemistry, and the relationship between CUEDC2 and the clinicopathological data was analyzed. Results Firstly, 28 cases （ 59.6% ） were positive for CUEDC2. Secondly, CUEDC2 over-expression was positively correlated to higher histopathological grade （ P = 0. 037 ） , but not related to age, clinical stage, and lymph node metastasis. Thirdly, the recurrence rate and mortality rate of the positive group were higher than that of the negative group, but single factor Log-Rank analysis showed the progression-free survival time and overall survival time of the positive group had no statistical significance as compared to the negative group （P 〉 0. 05 ）. Conclusions The positive expression rate of CUEDC2 increases with the histopathological grade, and therefore CUEDC2 can be regarded as a poor prognosis indicator for ovarian serous carcinoma.
出处
《诊断病理学杂志》
CSCD
2015年第4期237-240,共4页
Chinese Journal of Diagnostic Pathology
基金
解放军总医院苗圃基金面上课题(13KM47)
