摘要
目的:探讨不同ALT水平HBe Ag阴性慢性乙肝肝炎(CHB)患者中医证型分布特点及与病毒载量之间的关系。方法:将114例HBe Ag阴性CHB患者进行中医辨证分型,分为湿热中阻型、肝郁脾虚型、瘀血阻络型、肝肾阴虚型、脾肾阳虚型5型,再按ALT水平分为≥2×ULN组和<2×ULN组,比较2组间中医证型分布特点及与HBV DNA载量的相关性。结果:在ALT≥2×ULN组患者中,湿热中阻型所占比例最高(48.4%),其次为肝郁脾虚型、瘀血阻络型、肝肾阴虚型、脾肾阳虚型;而在ALT<2×ULN组患者中,以肝郁脾虚型和瘀血阻络型分布为主,所占比例分别为38.5%和34.6%,2组间中医证型分布比较有差异(P<0.01)。HBV DNA载量在湿热中阻型最高,其他各型由高到低分别为湿热中阻型>肝郁脾虚型>肝肾阴虚型>瘀血阻络型>脾肾阳虚型。ALT≥2×ULN组患者HBV DNA载量明显高于ALT<2×ULN组,2组间HBV DNA载量比较,差异有统计学意义(P<0.01)。结论:ALT水平与中医证型分布存在相关性,中医证型与病毒载量有一定关系,尤其湿热中阻型与病毒载量关系密切,可作为慢乙肝中医证型客观化指标之一。
Objective： Explore different ALT HBeAg negative chronic hepatitis b hepatitis（CHB） patients with TCM syn- drome type distribution characteristics and the relationship between viral load. Methods： 114 HBeAg negative CHB pa- tients of traditional Chinese medicine were divided into hot and humid resistance type, change the type, the resistance to blood stasis in collaterals, liver-kidney Yin deficiency,spleen kidney Yang deficiency type 5 type,press the ALT levels are divided into 2x ULN or higher and 〈 2x ULN two group,the comparison between the two groups of TCM syndrome type distribution characteristics and the correlation with HBV DNA loads. Results： （1）In patients with ALT or 2 x ULN group, dampness heat resistance in the proportion of the highest（48.4%）, followed by change the type of winding type, liver and kidney Yin deficiency, blood stasis resistance type, spleen and kidney Yang deficiency type;In ALT 〈 2 x ULN group of patients, in order to change the type and blood stasis resistance winding type distribution is given priority to, accounted for 38.5% and 34.6%, respectively; There are differences between the TCM syndrome type distribution compared between the two groups（P 〈 0.01）. （2）HBV DNA load resistance type is highest in the damp and hot, other each model from high to low, respectively in the damp and hot resistance type 〉 〉 change the type liver and kidney Yin deficiency type 〉 blood stasis resistance winding type 〉 spleen kidney Yang deficiency type.（3）the ALT acuity patients with HBV DNA load 2 x ULN group was obviously higher than that of ALT 〈 2 x ULN group, HBV DNA load comparison between the two groups, the difference was statistically significant（P 〈 0.01）. Conclusions： ALT level and no correlation between TCM syndrome type distribution,relationship between TCM syndrome type and viral load to a certain extent, especially in the wet and heat resistance type close to viral load,and can be used as the treatment of chronic hepatitis b in tradi
出处
《中医药临床杂志》
2015年第4期484-486,共3页
Clinical Journal of Traditional Chinese Medicine
基金
艾滋病和病毒性肝炎等重大传染病防治"十二五"科技重大专项(课题编号2012ZX100050004-002)
关键词
慢性乙肝肝炎
中医证型
丙氨酸氨基转移酶
病毒载量
chronic hepatitis b hepatitis, distribution of TCM syndromes, Alamine aminotransferase, Viral load
