摘要
目的 探讨甘草酸二铵注射液对重症暴发性病毒性心肌炎患儿炎症因子、心肌酶谱（CK-MB）和肌钙蛋白的影响及其治疗效果.方法 选择2012年1月～2014年5月广东省妇幼保健院收治的76例小儿重症暴发性病毒性心肌炎患者为研究对象,采用数字表法随机分为观察组和对照组,每组各38例,所有患者均给予基础治疗,观察组在基础治疗的基础上给予甘草酸二铵注射液静脉滴注,对照组给予地塞米松静脉滴注,观察2组炎症因子、心肌酶谱、肌钙蛋白水平及临床疗效.结果 观察组治疗有效率、心电图恢复有效率（89.47％、92.11％）均明显高于对照组（68.42％、73.68％）（P＜0.05）;治疗后2组白介素6（interleukin-6,IL-6）、白介素8（interleukin-8,IL-8）、肿瘤坏死因子α（tumor necrosis factorα,TNF-α）、肌酸激酶（creatine kinase-MB）、心肌肌钙蛋白Ⅰ（cardiac troponin Ⅰ,cTnI）心肌肌钙蛋白T（cardiac troponin T,cTnT）水平显著降低,且观察组的IL-6、IL-8、TNF-α、CK-MB、cTnI、cTnT水平均显著低于对照组（P＜0.05）.结论 甘草酸二铵注射液能够降低重症暴发性病毒性心肌炎患儿IL-6、IL-8、TNF-α、心肌酶、肌钙蛋白水平,提高治疗效果.
Objective To investigate influence of diammonium glycyrrhizinate injection on inflammation factors,CK- MB,troponin and therapeutic effect in treatment of severe fulminating viral myocarditis. Methods 76 children with severe fulminant viral myocarditis from Jan 2012 to May2014 in Guangdong Provincial Maternity and Child Care Center were selected as study subject and divided into observation group and control group by random digital table method,38 cases in each group. All patients were given basic treatment,patients in observation group were given diammonium glycyrrhizinate injection,and patients in control group were given dexamethasone. The clinical efficacy,inflammation factors,cardiac enzymes,and troponin of two groups were detected and compared. Results The treatment efficacy and electrocardiogram（ ECG） recovery efficacy of observation group were（ 89. 47%,92. 11%）,which were significantly higher than those of control group（ 68. 42%,73. 68%）（ P〈 0. 05）. After treatment,the IL-6,IL-8,TNF-α,CK-MB,c Tn I,c Tn T levels of two groups significantly reduced,and the above indexes of observation group were significantly lower than those of control group（ P〈 0. 05）. Conclusion Diammonium glycyrrhizinate injection could effectively reduce IL-6,IL-8,TNF-α,myocardial enzymes,and troponin levels of patients with severe fulminating viral myocarditis,and improve the treatment effect.
出处
《中国生化药物杂志》
CAS
2015年第2期104-106,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
暴发性病毒性心肌炎
甘草酸二铵注射液
炎症因子
心肌酶
肌钙蛋白
severe fulminating viral myocarditis
diammonium glycyrrhizinate injection
inflammation factor
myocardial enzymes
troponin
