摘要
目的研究奥硝唑在辅助法莫替丁治疗慢性胃炎中对疗效及安全性的影响,为临床治疗提供指导。方法 146例慢性胃炎患者,随机分为观察和对照两个研究组,每组73例。对照组给予法莫替丁片(20mg,每日2次)治疗;观察组同时给予法莫替丁片(20 mg,每日2次)和奥硝唑片(25 mg,每日2次)治疗。1个月为一个疗程,连续治疗2个疗程后比较两组的疗效、安全性、治疗依从性。结果观察组总有效率为93.2%高于对照组82.2%;观察组复发率为8.2%低于对照组21.9%;观察组不良反应发生率为4.1%低于对照组13.7%;治疗依从性观察组优于对照组,P<0.05,差异均具有统计学意义。结论奥硝唑辅助法莫替丁治疗慢性胃炎能够提高有效率,降低复发率,改善安全性及治疗的依从性。
Objective To explore the ornidazole in auxiliary famotidine therapy on the efifcacy and safety of chronic gastritis, and provide guidance for clinical treatment.Methods 146 chronic gastritis patients were randomly separated into the observe group and the control group, 73 cases in each group. The control group received Famotidine （20 mg, bid/d）. The observe group received Famotidine Tablets （20 mg, bid/d） and ornidazole tablets （25 mg, bid/d）. One month is a treatment course. After two courses of continuous treatment, we compared the curative effect, safety, compliance between the two groups.Results Total effective rate 93.2% in the observe group was higher than 82.2% in the control group. The recurrence rate 8.2%in the observation group was lower than 21.9% in the control group. In the comparision of safety, the incidence adverse reactions in the observe group （4.1%） was lower than that in the control group （13.7%）. The observe group was better than the control group in the treatment compliance （P〈0.05） the difference had statistical signiifcance.Conclusion In the treatment of chronic gastritis, Ornidazole auxiliary famotidine can improve efifciency, reduce the recurrence rate, and improve safety and compliance of treatment.
出处
《中国继续医学教育》
2015年第10期198-200,共3页
China Continuing Medical Education
关键词
奥硝唑
法莫替丁
慢性胃炎
疗效
安全性
Ornidazole
Famotidine
Chronic gastritis
Curative effect
Safety
