摘要
以5-溴烟酸为原料,经酯化、Suzuki反应、Na BH4还原、氯代四步反应以50%的总收率合成了5-(4-氟苯基)-3-氯甲基吡啶,其结构经1H-NMR确认无误。与文献报道方法相比较,新路线减少了副反应的发生、简化工艺操作、降低了分离难度、提高了收率和产品纯度,适合于低成本规模化生产。
Started from 5- Bromonicotinic acid,5-（ 4- fluorophenyl）- 3- chloromethyl pyridine was synthesized by employing five steps of reaction with esterification,Suzuki coupling,sodium tetrahydroborate reduction and chlorination.Structure of products was characterized by^1H- NMR. Compared with reported methods,this route suppressed side reactions,simplified reaction and isolation process,and increased yield and purity. It was suitable for industrialized production.
出处
《广州化工》
CAS
2015年第8期67-68,98,共3页
GuangZhou Chemical Industry
基金
烟台大学博士科研启动基金项目(HY07B30)
