摘要
目的探讨核黄素转运蛋白(riboflavin transporters,RFT2)多态变异性在宫颈癌组织及癌旁组织中的表达情况。方法将2003-01/2012-12月作者医院病理科确诊的宫颈癌组织临床资料作为研究组(120例),选取120例癌旁组织中的正常宫颈黏膜标本作为对照组,采用免疫组织化学法检测两组标本癌组织中RFT2的表达情况。结果经免疫组织化学法检测,研究组的RFT2阳性强度与对照组差异有统计学意义(Z=-8.754,P=0.000),研究组阳性强度大于对照组;不同临床分期的RFT2阳性强度表达差异无统计学意义(Z=-0.277,P=0.782)。结论 RFT2在宫颈癌组织中表达增高,可能促进宫颈癌发病,临床上应予以重视。
Objective To study the riboflavin transporters （Riboflavin transporters RFT2） polymorphism variation in cervical cancer tissue and the expression of tissue adjacent to carcinoma.Methods The clinical data of confirmed cervical cancer tissue between January 2003 and December 2012 in our department were as research group （120 cases） , the normal cervical mucosa specimens of 120 cases of carcinoma adjacent tissues were as control group. Immunohistochemical method was utilized to detect the expression of two groups of specimens in the cancer tissue RFT2 situation.Results The immunohistochemical detection indicated that the RFT2 positive strength between two groups were significantly different （Z = 8.754,P = 0.000） , which was greater in research group. RFT2 positive expressions in different clinical stages were not significantly different （Z = 0.277, P = 0.277）.Conclusion High RFT2 expression in cervical cancer tissue may promote cervical cancer incidence which should be focused in clinic.
出处
《华南国防医学杂志》
CAS
2014年第7期630-632,共3页
Military Medical Journal of South China
关键词
核黄素转运蛋白
宫颈癌
发病机制
Riboflavin transporters
Cervical cancer
Pathogenesis
