摘要
目的:探讨高通量血液透析在治疗尿毒症患者中的应用效果。方法:将120例尿毒症患者随机等分为高通量组和低通量组,高通量组应用高通量血液透析,低通量组应用低通量血液透析。比较两组患者血液透析治疗前后血清肌酐(Scr)、尿素氮(BUN)、血钾(K+)、β2-微球蛋白(β2-MG)、血清甲状旁腺激素(IPTH)、血红蛋白(Hb)的变化情况。比较两组患者血液透析期间低血压、感染等不良反应的发生率。结果:两组患者在血液透析治疗前后Scr,BUN,K+差异无统计学意义(P>0.05)。高通量组在透析治疗后β2-MG,IPTH水平低于低通量组(P<0.05),Hb高于低通量组(P<0.05)。两组患者血液透析后低血压、感染等不良反应的发生率差异无统计学意义(P>0.05),两组患者耐受性好。结论:采用高通量血液透析治疗尿毒症能有效清除中大分子毒素如β2-MG、IPTH等,减少透析的慢性并发症,改善患者生活质量。
Objective：To observe the clinical effects of uremic patients by the high - flux hemodialysis. Methods：120 cases of uremic patients admitted in nephrology of our hospital were randomly divided into the high - flux hemodialysis group and the low - flux hemodialysis group. Compared the serum creati-nine,the blood urea nitrogen,and serum potassium,β2 - microglobulin and serum parathyroid hormone before and after hemodialysis. Compared the change of hemoglobin and infection before and after hemodialysis. Results：The serum creatinine,the blood urea nitrogen and serum potassium of the high - flux he-modialysis group were not significantly different,compared with those of the low - flux hemodialysis group before hemodialysis,（P 〉 0. 05）. The β2 - micro-globulin levels and IPTH in the high - flux hemodialysis group were significantly lower than those in the low - flux hemodialysis group after hemodialysis（P〈 0. 05）. The hemoglobin levels in the high - flux hemodialysis group was significantly higher than those in the low - flux hemodialysis group after hemodi-alysis（P 〈 0. 05）. The hypotension,the infection and other adverse reactions in the high - flux hemodialysis group were not significantly different,compared with those in the low - flux hemodialysis group after hemodialysis（P 〉 0. 05）. There was low incidence rate of adverse reactions in the two groups. Conclu-sion：The high - flux hemodialysis treatment can effectively remove macromolecular uremic toxins such as β2 - microglobulin,IPTH,can effectively reduce chronic complications of hemodialysis and can effectively improve quality of life for patients.
出处
《护理实践与研究》
2015年第4期24-26,共3页
Nursing Practice and Research
