摘要
半个多世纪以来,活性维生素D3,即1,25-二羟维生素D3[1-25(OH)2D3]在糖尿病相关治疗研究中成为热点。由于1-25(OH)2D3及其特异性受体在糖尿病肾病中有一定抑制肾脏纤维化作用而备受关注。其可能通过参与抑制肾素-血管紧张素系统激活、减少纤维化因子释放及氧化应激等过程发挥作用,目前机制尚未完全明确。该文针对1-25(OH)2D3及其受体在肾脏中的表达及其相互作用进行阐述,以期为糖尿病的预防和诊治带来新的契机。
For more than half a century,the research of active vitamin D3（1,25-（OH） 2D3） has been the hot spot of diabetic nephropathy（DN） therapy.Active vitamin D3 and its specific receptors vitamin D receptor（VDR） play a protective role in renal fibrosis of DN.It may suppress the activation of renin-angiotensin system（RAS） system,reduce the release of fibrosis factors and the oxidative stress,though the underlying mechanism is still unclear.Here mainly expounds the positive effects and interaction of active vitamin D3 and VDR in the regulation of DN which may bring a new opportunity for the prevention and treatment of DN.
出处
《医学综述》
2015年第7期1257-1260,共4页
Medical Recapitulate
