摘要
骨膜蛋白（Periostin）是一种由结缔组织细胞分泌的细胞外基质蛋白,存在于人类多种正常组织中.Periostin能够参与胶原形成、组织纤维化、上皮间充质转换、恶性肿瘤发展以及多种损伤修复机制.最新研究表明,在哮喘气道重塑的病理过程中,periostin作为IL-4及IL-13的下游信号通过自分泌或旁分泌的方式与其他细胞外基质蛋白相互作用参与上皮下纤维化.研究periostin在哮喘气道重塑中可能扮演的角色及其发挥作用的机制,可能对哮喘的防治提供新的思路.
Periostin is a extracellular matrix protein secreted by connective tissues.It is expressed in many normal human tissues.Periostin participates in collagen formation,fibrosis,epithelialmesenchymal transition,tumor development and a variety of injury-repair mechanisms.Recent studies show that in the pathogenesis of airway remodeling in bronchial asthma,periostin works as a downstream signal of IL-4 and IL-13.It interacts with extracellular matrix proteins and promotes subepithelial fibrosis through autocrine or paracrine.Studying the exact role of periostin in airway remodeling and the related mechanism will provide new strategies for the prevention of bronchial asthma.
出处
《国际呼吸杂志》
2015年第7期528-531,共4页
International Journal of Respiration
