摘要
目的:对比观察喹硫平与氟哌啶醇治疗老年痴呆患者精神行为症状的临床疗效和安全性。方法:选取2012年7月—2013年8月收治的老年痴呆伴精神行为功能障碍患者164例,以随机数字表法分为喹硫平组和氟哌啶醇组各82例,前者给予喹硫平(145±50)mg/d治疗,后者给予氟哌啶醇(4.5±1.5)mg/d治疗。治疗2周后,观察2组患者的痴呆病理性评分、疗效及不良反应发生情况。结果:治疗后,2组患者的痴呆病理性评分均明显降低,2组治疗前后的差异均有统计学意义(P<0.05);治疗后,喹硫平组患者的痴呆病理性评分明显低于氟哌啶醇组,差异有统计学意义(P<0.05)。氟哌啶醇组患者不良反应发生率为46.9%(35/82),喹硫平组为31.3%(26/82),喹硫平组患者的不良反应发生率明显低于氟哌啶醇组,差异有统计学意义(P<0.05)。结论:与氟哌啶醇相比,喹硫平治疗老年痴呆患者精神行为症状的疗效更显著,且不良反应发生率低,能有效促进老年痴呆患者精神行为功能快速恢复。
OBJECTIVE： To evaluate the efficacy and safety of quetiapine vs. haloperidol in the treatment of mental behavioral symptoms in patients with senile dementia. METHODS： A total of 164 patients with senile dementia complicated by mental behavioral disorder who were seen in our hospital between July 2012 and August 2013 were randomly assigned to receive either quetiapine at a dose of（ 145 ± 50） mg / day or haloperidol at a dose of（ 4. 5 ± 1. 5）mg / day,of 82 cases in each group. After treatment of two weeks,the pathological score for dementia,the curative efficacy and safety in the two groups were followed. RESULTS： Both groups showed significantly reduced pathological score for dementia after treatment compared with before treatment（ P〈0. 05） with that in quetiapine-treated group significantly lower than in haloperidol-treated group（ P〈0. 05）; the incidence of adverse reactions in quetiapinetreated group was significantly lower than in haloperidol-treated group[31. 3%（ 26 /82） vs. 46. 9%（ 35 /82）,P〈0. 05]. CONCLUSIONS： Compared with haloperidol,quetiapine is more safe and effective and it can promote the rapid recovery of mental behavioral symptoms in patients with senile dementia.
出处
《中国医院用药评价与分析》
2015年第3期379-380,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
喹硫平
氟哌啶醇
老年痴呆
精神行为
对照研究
Quetiapine
Haloperidol
Senile dementia
Mental behavior
Control study
