摘要
目的探讨喹硫平与奥氮平治疗老年期痴呆患者精神行为障碍的临床疗效。方法抽取60例老年期痴呆患者,随机分为试验组和对照组,各30例,对照组予喹硫平治疗,试验组予奥氮平治疗。比较两组患者的痴呆病理行为(BEHAVE-AD)评分、精神状况(MMSE)评分及日常生活能力(ADL)评分。结果治疗后,两组患者BEHAVE-AD评分比较,差异有统计学意义(P<0.05);两组间的MMSE评分、ADL评分比较,差异无统计学意义(P>0.05)。结论喹硫平与奥氮平均可用于治疗老年期痴呆患者精神行为障碍,但奥氮平的短期疗效更好,临床价值更大。
Objective To investigate the clinical efficacy of quetiapine and olanzapine in the treatment of mental disorders in elderly patients with dementia. Methods 60 patients with senile dementia were randomly divided into the experimental group and the control group, 30 cases in each group. The control group was treated with quetiapine, and the treatment group was treated with olanzapine. The BEHAVE-AD scores, MMSE scores, and ADL scores were compared between the two groups. Results After treatment, the groups had statistically significant difference on BEHAVE-AD scores （ P 〈 0. 05 ）; on the MMSE scores and ADL scores, the two groups had no statistically significant difference （ P 〉 0. 05 ） . Conclusion Both drugs can be used to treat mental disorders in elderly patients, but the short-term efficacy of olanzapine is better, and its clinical value is greater.
出处
《中国药业》
CAS
2017年第3期45-47,共3页
China Pharmaceuticals
