摘要
目的:观察联合应用复方阿嗪米特肠溶片和复合营养素(Noveliver),对失代偿期肝硬化患者血清白蛋白(albumin,ALB)、前白蛋白(pre-albumin,PA)水平及腹水的发生情况和严重程度的影响.方法:共有35例失代偿期肝硬化纳入研究,包括20例治疗组患者接受复方阿嗪米特肠溶片联合复合营养素(Noveliver)治疗加常规药物治疗,15例只接受常规药物治疗.随访12 wk,随访期限内,收集两组患者腹水的发生情况及严重程度;检测两组患者血清ALB及PA水平.结果:在治疗后12 wk,复方阿嗪米特肠溶片联合复合营养素(Noveliver)治疗组腹水改善情况显著优于对照组(P<0.05).治疗组血清PA及ALB水平逐渐增加,其中血清PA水平在治疗后4 wk时(110.3 mg/L±14.6mg/L vs 100.8 mg/L±7.5 mg/L,P<0.05)、ALB在治疗后8 wk时(31.9 g/L±2.5 g/L vs29.8 g/L±2.1 g/L,P<0.05)即显著高于对照组,两组差异有统计学意义(P<0.05),并持续至12 wk.结论:复方阿嗪米特肠溶片联合复合营养素(Noveliver)改善失代偿期肝硬化患者的营养状况,提高血清ALB及PA的水平,改善腹水的发生情况及严重程度.
AIM：To observe the effect of compotind azintamide enteric-coated tablet combined with compound nutrients（Noveliver） on serum albumin（ALB）and pre-albumin（PA） levels in patients with decompensated liver cirrhosis.METHODS：A total of 35 inpatients with decompensated liver cirrhosis were enrolled in this trial,including 20 patients treated with compound azintamide enteric-coated tablet combined with compound nutrients（Noveliver）plus routine medical treatment,and 15 patients receiving routine medical treatment only as controls.The efficacy of compound azintamide enteric-coated tablet combined with compound nutrients（Noveliver） was monitored during a12-week follow-up period.RESULTS：After treatment with compound azintamide enteric-coated tablet combined with compound nutrients（Noveliver）,serum PA and ALB levels increased gradually.PA levels at 4 wk after treatment were 110.3 mg/L ± 14.6mg/L vs 100.8 mg/L ± 7.5 mg/L（P 〈0.05） in the treatment group and control group.ALB levels at 8 wk after treatment and 31.9 g/L ± 2.5 g/L vs 29.8 g/L ± 2.1 g/L（P 〈0.05） in the treatment group and control group.The efficacy continued to 12 wk after treatment.CONCLUSION：Compound azintamide enteric-coated tablet combined with compound nutrients（Noveliver） improves the nutritional status of patients with decompensated cirrhosis,increases serum ALB and PA levels,and reduces the incidence and severity of ascites.
出处
《世界华人消化杂志》
CAS
2015年第10期1644-1648,共5页
World Chinese Journal of Digestology
基金
河南省卫生厅医学科技攻关基金资助项目
No.2011020122~~
关键词
复方阿嗪米特肠溶片
复合营养素
失代偿期肝硬化
血清白蛋白
血清前白蛋白
Compound azintamide entericcoated tablet
Compound nutrients（Noveliver）
Decompensated liver cirrhosis
Serum albumin
Serum pre-albumin
