摘要
目的探讨并分析肥胖2型糖尿病肾病患者临床及病理特点。方法对经肾活检确诊的120例糖尿病肾病患者临床资料进行回顾性分析。结果 120例糖尿病肾病患者中有55例为肥胖2型糖尿病肾病患者,所占比例为45.8%,其中女性占据多数,中腹型肥胖占多数。相对于正常体质量患者而言,肥胖患者脂肪肝的发生率(36.4%)、空腹胰岛素(23.33±24.01)IU/L以及C钛(1.12±1.26)ng/uL均比较高。肥胖组患者的病程(68.34±63.46)个月显著比正常体质量患者短,且糖尿病到肾损害的时间(41.35±80.73)个月也更短,eGFR(32.7%)显著高于对照组,其肾脏病理主要表现肾小球的面积以及直径明显增大,二者比较差异有统计学意义(P<0.05)。结论肥胖2型糖尿病肾病患者合并严重代谢紊乱,蛋白尿出现较早,
Objective To investigate and analyze the obese type 2 diabetic nephropathy patients with clinical and pathological characteristics. Methods In Bazhong City, Sichuan Province in Ping chang People＇s Hospital from April 2012-september 2013 menstrual renal biopsy confirmed 120 cases of diabetic nephropathy in patients with clinical data were retrospectively analyzed. Results 120 cases of patients with diabetic nephropathy in 55 cases of obese type 2 diabetic nephropathy, the proportion of 45.8%, in which the female majority, abdominal obesity accounted for the majority of. Compared with patients with normal body mass, the incidence of obesity patients with fatty liver （36.4%）, fasting insulin （IU/L） and （23.33 ＋ 24.01）C titanium （1.12 ＋ 1.26）ng/uL are relatively high. Obese course （68.34 ＋ 63.46）months significantly than normal weight patients with short, and diabetes to renal damage in time （41.35 ~ 80.73）months is shorter, eGFR （32.7%） was significantly higher than that of the control group, the renal pathology mainly glomerular area and diameter increased significantly, there were statistically significant difference between them （P〈0.05）. Conclusion from the results of this research, obese type 2 diabetic nephropathy patients with severe metabolic disorders, urinary protein appeared earlier, glomerular hyperfiltration status and high perfusion state significantly, delaying early weight loss in favor of renal damage in patients with type 2 diabetic nephropathy and development.
出处
《当代医学》
2015年第11期62-63,共2页
Contemporary Medicine
关键词
病理
肥胖
特点
2型糖尿病肾病
临床
Pathology
Obesity
Features
Type 2 diabetic nephropathy
Clinical
