摘要
微透析技术(MD)是一种在不破坏机体内环境的前提下,对生物体细胞间液内源性或外源性物质进行连续取样和分析的微量生化取样技术。MD不仅可用于监测药物在内脏和肿瘤中的局部药代动力学,还可研究具有代谢产物与器官特异性的病理生理过程,并且有可能作为器官和肿瘤局部药物直接传递和评估工具。笔者就MD在胰腺研究相关应用作一概述,讨论其优势和局限性,并进行展望。
Microdialysis（MD） is a biochemical micro-detection technique that can continuously sample and analyze the endogenous or exogenous substances in the intercellular l uid, with no impact on the internal environment of the organism. MD can be used to determine not only the local drug pharmacokinetics in internal organs or tumors but also the pathophysiological processes that have metabolic products or organ specificity, and even may be used as an approach for direct delivery and assessment of the local drug in organs and tumors. In this paper, the authors address the application of MD in dealing with pancreas-related research, and discuss its advantages and limitations, as well as the future prospects.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2015年第3期413-417,共5页
China Journal of General Surgery
