摘要
目的研究新生儿发生医院感染的细菌分布特点与耐药性,为临床治疗提供参考。方法回顾性分析2012-2014年150例新生儿发生医院感染的细菌培养及药敏试验结果,数据采用WHO-NET5.4进行统计处理。结果共1 238例新生儿送检标本中150例培养阳性,感染率12.1%;150例感染新生儿中有32例新生儿发生复合感染,复合感染率21.3%;共检出182株病原菌,以革兰阴性菌为主,共112株占61.5%;4种主要革兰阴性菌对亚胺培南、环丙沙星、阿米卡星较为敏感,铜绿假单胞菌对头孢类抗菌药物耐药率>50.0%;耐甲氧西林金黄色葡萄球菌仅对万古霉素敏感,对其他各种抗菌药物的耐药性均高于甲氧西林敏感金黄色葡萄球菌。结论临床应根据药敏试验合理选择抗菌药物。
OBJECTIVE To study neonatal bacteria distribution and drug resistance of nosocomial infections,so as to provide the reference for the clinical treatment.METHODS The bacteria culture and drug sensitive test results of 150 cases of neonatal nosocomial infections were analyzed retrospectively from 2012 to 2014.All data were statistically analyzed by WHO-NET 5.4software.RESULTS A total of 150 cases were detected to be bacteriapositive in the all 1238 neonatal cases and the infection rate was 12.1%.Among the 150 cases,32cases proved to be combined infections with the rate of 21.3%.Totally 182 strains of pathogens were detected.Gram-negative bacteria dominated the majority with 112 strains,accounting for 61.5%.The 4main gram-negative bacteria were sensitive to imipenem ciprofloxacin and amikacin.More than 50% Pseudomonas aeruginosa were resistant to cephalosporin.Methicillin-resistant Staphylococcus epidermidis were only sensiti to vancomycin and had high drug resistance rate than other antibiotics to methicillin-resistant Staphylococcus epidermidis.CONCLUSION Antibiotics should be chosen reasonably according to the drug sensitive test in clinic.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第7期1660-1662,共3页
Chinese Journal of Nosocomiology
基金
浙江省科技厅公益技术研究社会民展基金资助项目(2012c33052)
关键词
新生儿
医院感染
细菌分布
耐药
Newborn
Nosocomial infection
Bacterial distribution
Resistance
