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甲状腺癌基础研究的几个热点问题 被引量：9

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摘要 甲状腺癌是最常见的内分泌系统恶性肿瘤,在头颈部恶性肿瘤占首位,在所有恶性肿瘤中约占3％,且女性发病率较高.甲状腺癌包括甲状腺乳头状癌、滤泡状甲状腺癌、未分化甲状腺癌和甲状腺髓样癌.近年来我国甲状腺癌的发病率呈逐年上升的趋势.尽管甲状腺癌的总死亡率保持平稳,但每年因甲状腺癌死亡的绝对数却在不断上升.随着甲状腺癌发病率的升高,研究人员越来越重视甲状腺的基础研究,近年来关于甲状腺癌发生发展机制的研究取得了巨大进展.然而目前对甲状腺癌更深一层的基础研究仍然在探索之中,特列出以下几个较为热点的问题进行探讨和研究.
作者 殷德涛 许建辉
机构地区 郑州大学第一附属医院甲状腺外科河南省高等学校临床医学重点学科开放实验室
出处 《中华医学杂志》 CAS CSCD 北大核心 2015年第12期885-887,共3页 National Medical Journal of China
基金 国家自然科学基金（81372863） 郑州市科技领军人才项目（131PLJRC676）
关键词 滤泡状甲状腺癌 头颈部恶性肿瘤 甲状腺乳头状癌 未分化甲状腺癌 甲状腺髓样癌 癌发病率 总死亡率 内分泌系统
分类号 R736.1 [医药卫生—肿瘤]
  • 相关文献

参考文献16

  • 1殷德涛,陈国,李红强,郑湘予,王勇飞,张艳,江金花,王庆端.甲状腺乳头状癌中XAFl基因启动子甲基化及其蛋白表达的相关性[J].中华医学杂志,2012,92(28):1967-1970. 被引量：7
  • 2Yin DT, Wu W, Li M, et al. DKK3 is a potential tumor suppressor gene in papillary thyroid carcinoma [J]. Endoer Relat Cancer,2013,20(4) :507-514. 被引量：1
  • 3Rajoria S, Suriano R, Shanmugam A, et al. Metastatic phenotype is regulated by estrogen in thyroid cells [ J ]. Thyroid, 2010,20 (1) :33-41. 被引量：1
  • 4Chen GG, Vlantis AC, Zeng Q, et al. Regulation of cell growth by estrogen signaling and potential targets in thyroid cancer [ J ]. Curr Cancer Drug Targets,2008,8 (5) :367-377. 被引量：1
  • 5Kumar A, Klinge CM, Goldstein RE. Estradiol-induced proliferation of papillary and follicular thyroid cancer cells ismediated by estrogen receptors alpha and beta[ J]. Int J Oncol, 2010,36(5) :1067-1080. 被引量：1
  • 6Paunovic I, Isic T, Havelka M, et al. Combined immunohistochemistry for thyroid peroxidase, galectin-3, CK19 and HBME-1 in differential diagnosis of thyroid tumors [J]. APMIS, 2012,120 ( 5 ) : 368-379. 被引量：1
  • 7Yang I-I, Zhong H, Leung K, et al. Structure-based design of flavone derivatives as c-myc oncogene down-regulators [ J ]. Eur J Pharm Sci ,2013,48 (1-2) : 130-141. 被引量：1
  • 8Henderson YC, Shellenberger TD, Williams MD, et al. High rate of BRAF and RET/PTC dual mutations associated with recurrent papillary thyroid carcinoma[ J ]. Clin Cancer Res, 2009,15 ( 2 ) : 485-491. 被引量：1
  • 9Yin DT, Wang L, Sun J, et al. Homozygous deletion hut not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma [J]. Ann Clin Lab Sei,2010,40(3) :267-272. 被引量：1
  • 10殷德涛,许建辉,王勇飞,李红强,张艳,江金花,王庆端.CCDC67基因mRNA在甲状腺乳头状癌中的表达及临床意义[J].中华医学杂志,2014,94(30):2382-2385. 被引量：7

二级参考文献30

  • 1魏香,曾宪纲,周海梦.蛋白质结构中卷曲螺旋的研究进展[J].中国生物化学与分子生物学报,2004,20(5):565-571. 被引量：21
  • 2Yin DT, Wang L, Sun JR, et aI. Association of the promoter methylation and protein expression of Fragile Histidine Triad (FHIT) gene with the progrossion of differentiated thyroid carcinoma. Int J Clin Exp Pathol, 2010,3:482-491. 被引量：1
  • 3Liston P, Fong WG, Kelly NL, et al. Identification of XAF1 as an antagonist of XIAP anticaspase activity. Nat Cell Biol, 2001,3 : 128-133. 被引量：1
  • 4Lee MG, Huh JS, Chung SK, et al. Promoter CpG hypermethylation and downregulation of XAF1 expression in human urogenital malignancies : implication for attenuated p53 response to apoptotic stresses. Oneogene, 2006,25:5807-5822. 被引量：1
  • 5Zhang F, Wu LM, Zhou L, et al. Predictive value of expression and promoter hypermethylation of XAF1 in hepatitis B virus- associated hepatocellular carcinoma treated with transplantation. Ann Surg Oncol, 2008,15:3494-3502. 被引量：1
  • 6Valdez BC, Li Y, Murray D, et al. 5-Aza-2'-deoxycytidine sensitizes busulfan-resistant myeloid leukemia cells by regulating expression of genes involved in cell cycle checkpoint and apoptosis. Leuk Res, 2010,34:364-372. 被引量：1
  • 7Wu M, Orta L, Gil J, et al. detection of XIAP and p63 in adenomatous hyperplasia, atypical adenomatous hyperplasia, bronchioloalveolar carcinoma. Mod Patho1,2008,21 : 553-558. 被引量：1
  • 8Li W, Ni GX, Zhang P, et al. Characterization of E2F3a Function in HepG2 liver cancer cells. J Cell Biochem,2010, 111:1244- 1251. 被引量：1
  • 9Yin DT, Wang L, Sun JR, et al. Homozygous deletion but not mutation of Exons 5 and $ of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma. Ann Clin Lab Sci, 2010, 40:267-272. 被引量：1
  • 10Wang J, Gu Q, Li M, et al. Identification of XAF1 as a novel cell cycle regulator though modulating G2/M checkpoint and interaction with checkpoint kinase 1 in gastrointestinal cancer. Carcinogenesis,2009, 30 : 1507-1516. 被引量：1

共引文献12

同被引文献63

  • 1Cook AM, Li L, Ho Y, et al. Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells[J]. Blood, 2014, 123(18):2826-2837. 被引量：1
  • 2Mitsutake N, Iwao A, Nagai K, et al. Characterization of side population in thyroid cancer cell lines: Cancer stem-like cells are enriched partly but not exclusively[J]. Endocrinology, 2007, 148(4):1797-1803. 被引量：1
  • 3Shimamura M, Nagayama Y, Matsuse M, et al. Analysis of multiple markers for cancer stem-like cells in human thyroid carcinoma cell lines[J]. Endocr J, 2014, 61(5):481-490. 被引量：1
  • 4Zito G, Richiusa P, Bommarito A, et al. In vitro identification and characterization of CD133(pos) cancer stem-like cells in anaplastic thyroid carcinoma cell lines[J]. PLoS One, 2008, 3(10):e3544. doi: 10.1371/journal.pone.0003544. 被引量：1
  • 5Friedman S, Lu M, Schultz A, et al. CD133+ anaplastic thyroid cancer cells initiate tumors in immunodeficient mice and are regulated by thyrotropin[J]. PLoS One, 2009, 4(4):e5395. doi: 10.1371/journal.pone.0005395. 被引量：1
  • 6Todaro M, Iovino F, Eterno V, et al. Tumorigenic and metastatic activity of human thyroid cancer stem cells[J]. Cancer Res, 2010, 70(21):8874-8885. 被引量：1
  • 7Takano T. Fetal cell carcinogenesis of the thyroid: a modified theory based on recent evidence[J]. Endocr J, 2014, 61(4):311-320. 被引量：1
  • 8Malaguarnera R, Frasca F, Garozzo A, et al. Insulin receptor isoforms and insulin-like growth factor receptor in human follicular cell precursors from papillary thyroid cancer and normal thyroid[J]. J Clin Endocrinol Metab, 2011, 96(3):766-774. 被引量：1
  • 9Zheng X, Cui D, Xu S, et al. Doxorubicin fails to eradicate cancer stem cells derived from anaplastic thyroid carcinoma cells: Characterization of resistant cells[J]. Int J Oncol, 2010, 37(2):307-315. 被引量：1
  • 10Yin D, Wang Q, Chen L, et al. Germline Stem Cell Gene PIWIL2 Mediates DNA Repair through Relaxation of Chromatin[J]. PLoS One, 2011, 6(11):e27154. doi: 10.1371/journal.pone.0027154. 被引量：1

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中华医学杂志
2015年 第12期

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