摘要
甲状腺未分化癌(ATC)是恶性度最高的肿瘤之一,但近年来预后也在悄然发生变化,陆续有临床成功治疗、生存时间明显延长的案例报道。笔者通过对1例79岁ATC患者的成功救治和3年多的随访及对45例ATC患者的临床分析,深感需重新审视ATC,亟需调整临床应对策略。ATC如果能早期诊断,并不失时机地采取以根治性手术为主的综合治疗,可极大改善相当一部分患者的预后,整体生存时间也会大幅度延长,有可能使相当一部分患者达到临床治愈。此外,基因检测和靶向治疗也为一部分患者的生存带来了新希望。
Anaplastic thyroid carcinoma(ATC)is one of the most malignant tumors.However,in recent years,the prognosis of the disease has also changed quietly,and there have been reports of successful clinical treatment and significantly prolonged survival time.Based on the successful treatment of a 79-year-old patient and more than three years of follow-up,as well as the clinical analysis of 45 ATC patients,the author deeply believes that it is necessary to re-examine the understanding of ATC and urgently adjust the clinical strategies.If ATC can be diagnosed early and treated by comprehensive treatment based on radical surgery,the prognosis of a considerable number of patients can be greatly improved,the overall survival time will be greatly prolonged,and a considerable number of patients may achieve clinical cure.In addition,genetic testing and targeted therapy bring a new hope for the survival of some patients.
作者
周一坤
施秉银
Zhou Yikun;Shi Bingyin(Department of Endocrinology,the First Affiliated Hospital of Xi′an Jiaotong University,Xi′an 710061,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2023年第5期375-377,共3页
National Medical Journal of China
基金
国家重点研发计划(2018YFC1311500、2018YFC1311501)
国家自然科学基金(81970679)
关键词
甲状腺肿瘤
甲状腺未分化癌
长期生存
根治性手术
早诊早治
Thyroid neoplasms
Anaplastic thyroid carcinoma
Long-term survival
Radical surgery
Early diagnosis and treatment
