摘要
制备良好的动物模型是科研过程中的重要环节。制作肝纤维化动物模型的化学方法中最常用的主要有四氯化碳(CCl4)法和硫代乙酰胺(TAA)法,该方法造模简单、成模率高,物理方法中主要为胆管结扎法,该方法操作复杂、成模率较低,但对其他组织器官无毒性作用。在磁共振检测的研究中,弥散加权、灌注成像及波谱成像能够对中重度肝硬化作出分期,但对轻中度肝纤维化分期尚有明显不足,而弥散张量成像在轻中度的肝纤维化的诊断中有较大优势。现就制备动物肝纤维化模型的常用方法及该模型MRI检测的研究方法的进展进行综述。
Preparation of good animal model is an important part of the process of scientific research.Carbon tetrachloride（CCl4）and Thioacetamide（TAA）are the mainly used agentia for making rabbit model of hepatic fibrosis in chemical method because of simplicity and highly success rate.The mainly used physical method is bile duct ligation.This method is complicated and success rate is low,however,it is non-toxic for other tissues and organs.In the research of MRI detection,DWI,PWI and MRS play agreat role in distinguishing moderate and severe hepatic cirrhosis,but,it is obviously insufficient to distinguish mild and moderate stages of liver fibrosis.DTI has great advantage in the diagnosis of mild and moderate stages of liver fibrosis.This article summarized the fibrosis model preparation of rabbits and the research methods progress in MRI of the model.
出处
《医学影像学杂志》
2015年第3期529-532,共4页
Journal of Medical Imaging
基金
上海市卫生局科研基金项目(20124193)
