摘要
以5-烃基-2-氨基-1,3,4-噻二唑和2-甲基-4-三氟甲基噻唑-5-甲酰氯为原料,在三乙胺的作用下合成了新型结构的标题化合物,并且发现化合物中与1,3,4-噻二唑基相连的苯环上有吸电子取代基的产率比苯环上无取代基的产率低。产物的结构用IR、1HNMR、13CNMR和元素分析进行了表征。测试了目标化合物的杀菌活性,其对所测菌种均表现出一定的杀菌活性,而且1,3,4-噻二唑环上连有烷基的活性明显高于连有芳基的活性。
Three new N-（ 1,3,4-thiadiazolyl） thiazole carboxamides were synthesized in moderate yields by reaction of 5-alkyl （ar- yl）-2-amino-l, 3,4-thiadiazoles with 2-methyl-4-trifluoromethylthiazol-5-carboxychloride in the presence of triethyl amine. The compound with electron-withdrawing group on the phenyl ring connected with 1,3,4-thiadiazolyl was formed in higher yield than those with unsubstituted phenyl group. The structures of the compounds were confirmed by IR, 1HNMR, 13CNMR and elemental analysis. The fungicidal activity of the compounds was also evaluated ,and moderate activity against the tested fungi was obtained. The compounds with alkyl group on the 1,3,4-thiadiazolyl ring exhibited higher activity than those with aryl group.
出处
《化学试剂》
CAS
北大核心
2015年第4期298-300,338,共4页
Chemical Reagents
基金
国家自然科学基金资助项目(21372070)
湖南省高校创新平台开放基金资助项目(13K089)
理论有机化学与功能分子教育部重点实验室开放基金项目(LKF1302)
关键词
噻唑甲酰胺
1
3
4-噻二唑
合成
杀菌活性
thiazole carboxamide
l, 3,4-thiadiazole
synthesis
fungicidal activity
