摘要
目的:评估蒙特利尔认知评估量表(Mo CA)在帕金森病伴轻度认知功能障碍患者中的应用价值。方法:首先收集帕金森病患者140例,经临床评估筛查出帕金森病伴轻度认知功能障碍组(PD-MCI组)71例和帕金森病不伴认知功能障碍组(PD-NC组)69例。对两组患者分别进行Mo CA和简易精神状态检查量表(MMSE)检测,最后根据两个量表的得分情况进行比较分析。结果:PD-MCI组的Mo CA和MMSE得分分别为(21.00±4.113)分和(27.62±2.344)分,结果明显低于对照组的(27.72±2.595)分和(28.75±1.566)分,具有显著差异(P<0.01)。以26分为界,Mo CA筛选敏感性为90.14%,特异性为79.71%,而MMSE敏感性仅为28.17%,特异性为96.65%。PD-MCI组患者在视空间与执行、注意、语言、抽象、延迟回忆、定向力等认知领域得分明显低于对照组(P<0.01)。结论:Mo CA量表是PD-MCI患者比较理想的筛查工具,与MMSE相比具有更高的敏感性。Mo CA量表在临床上的推广,有助于临床医师快速客观地评价PD患者早期的认知情况。
Objective: To determine the diagnostic value of Montreal cognitive assessment(MoCA) to evaluate mild cogni- tive impairment (MCI) for Parkinson's disease(PD) patients.
Method: A total of 140 participants were recruited: 71 patients were diagnosed as PD with MCI(PD-MCI group) and 69 patients as PD with normal cognitive function(PD-NC group). Both groups were assessed with MoCA and mini-mental state examination(MMSE). The discriminate validities of MoCA and MMSE as screen- ing and diagnostic instruments were ascertained.
Result: MoCA and MMSE scores were (21.00±4.113) and (27.62±2.344) in PD-MCI group respectively. These scores were significantly lower than that in PD-NC group(27.72±2.595, P〈0.01) and (28.75±1.566, P〈0.01) for MoCA and MMSE respectively. With a cut-off score of 26 points, MoCA showed sensitivity of 90.14% and specificity of 79.71% in the detection of MC! in PD patients, while MMSE showed 28.17% and 96.65% separately. PD-MCI group exhibited significant worse performance in digit, space, attention, verbal memory, ab- straction and language abilities(P〈 0.01).
Conclusion: The MoCA has adequate psychometric properties as a screening instrument for the detection of MCI in PD patients. It has higher sensitivity when compared with MMSE.
出处
《中国康复医学杂志》
CAS
CSCD
北大核心
2015年第3期251-254,共4页
Chinese Journal of Rehabilitation Medicine