摘要
目的观察左旋多巴联合普拉克索冶疗老年帕金森病痴呆（PDD）的临床效果。方法收集沈阳医学院第二附属医院2013-2017年收冶的老年PDD患者57例，随机分为对照组28例与观察组29例。对照组接受左旋多巴片单药治疗，观察组在对照组基础上加用普拉克索片。比较两组治疗前和治疗8周后的帕金森综合评分量表（UPDRS）、简易精神状态量表（MMSE）和蒙特利尔认知评估量表（MoCA）评分。结果两组患者冶疗前UPDRS、MMSE和MoCA评分差异均无统计学意义（P〉0．05）；冶疗8周后上述量表评分差异有统计学意艾（P〈0．05）。结论左旋多巴联合普拉克索治疗老年PDD可明显改善患者的生活质量和精神状态，值得推广应用。
Objective To observe the clinical effects of levodopa combined with pramipexole on senile parkinson disease dementia （PDD）. Methods A total of 57 senile PDD patients were collected from The Second Affiliated Hospital of Shenyang Medical College from 2013 to 2017, and randomly divided into observation group （29 cases） and control group （28 cases）. The patients in control group were treated with single levodopa, and the patients in observation group were treated with levodopa combined with pramipexole. The unified parkinson＇s disease rating scale （UPDRS）, mini-mental state examination （MMSE） and montreal cognitive assessment （MoCA） scores were compared before treatment and after 8-weeks treatment. Results There were no significant differences in UPDRS, MMSE and MoCA scores before treatment （P〉0.05）. After 8-week treatment, there were significant differences in UPDRS, MMSE and MoCA scores （P〈0.05）. Conclusion The application of levodopa combined with pramipexole could significantly improve the quality of life and mentality of PDD patients, which is worthy of extensive application.
作者
吴琼
WU Qiong(No.1 Neurology Department, The Second Affiliated Hospital of Shenyang Medical College, Shenayng 110002, Liaoning Province, China)
出处
《中国实用乡村医生杂志》
2018年第6期68-69,72,共3页
Chinese Practical Journal of Rural Doctor
