摘要
目的采用静息态功能磁共振(rs-fMRI)区域局部一致性(ReHo)技术,观察复发缓解型多发性硬化(RRMS)患者脑局部ReHo值。方法收集19例RRMS患者(RRMS组)与19名年龄、性别相匹配的健康对照者(对照组)行rsfMR和常规MR检查。分别提取两组左、右侧运动相关脑区ReHo值行两样本t检验分析,对RRMS组双侧运动相关脑区ReHo值与患者EDSS评分行相关性分析。结果与正常对照组相比,RRMS患者双侧运动相关脑区ReHo值降低(P<0.05,经AlphaSim校正,体素>20),患者双侧运动相关脑区ReHo值与EDSS评分均呈负相关(右侧:r=-0.819,P<0.05;左侧:r=-0.871,P<0.05)。结论 RRMS患者运动相关脑区神经元活动一致性存在减低改变,这种改变可能是患者运动功障碍形成的相关因素之一。
Objective To observe the regional homogeneity（ReHo）value of motor-related cortex in patients with relapsing-remitting multiple sclerosis（RRMS）using resting state functional magnetic resonance imaging（rs-fMRI）.MethodsNineteen patients with RRMS（RRMS group）and 19gender-and age-matched healthy controls（control group）underwent rs-fMRI and conventional MRI.Bilateral motor-related cortex were selected as ROIs to measure ReHo values and were analyzed by two sample t test,Correlation analysis was performed between the ReHo values and expended disability status scale（EDSS）.Results Compared with control group,the ReHo values of motor-related cortex in RRMS group decreased（P〈0.05,AlphaSimcorrection,voxel〉20）.The bilateral ReHo values showed negative correlation with EDSS（right r=-0.819,P〈0.05,left r=-0.871,P〈0.05）.Conclusion ReHo values of motor-related cortex in RRMS patients have been decreased,which may be one of the relevant factors related to disability.
出处
《中国医学影像技术》
CSCD
北大核心
2015年第3期327-330,共4页
Chinese Journal of Medical Imaging Technology
基金
国家自然科学基金(81371523)
国家临床重点专科建设项目([2013]544)
重庆市卫生局资助项目(2011-1-031
2012-1-017)
关键词
多发性硬化
局部一致性
功能磁共振成像
Multiple sclerosis
Regional homogeneity
Functional magnetic resonance imaging
