摘要
目的：研究右美托咪定对七氟醚复合骶管阻滞小儿麻醒期躁动的预防作用及炎症应激反应的影响。方法：将2012年3月~2014年6月期间在我院接受腹部以下手术的90例患儿纳入研究,随机分为两组,并接受七氟醚复合骶管阻滞麻醉,观察组在麻醉诱导完成后给予右美托咪定静脉注射,对照组给予等剂量生理盐水静脉注射,比较两组患儿的生命体征指标、炎症反应指标以及应激反应指标。结果：（1）生命体征：观察组患儿的心率（HR）、心脏指数（CI）和心脏与收缩压乘积（RPP）均低于对照组（P〈0.05）;（2）炎症反应：观察组患儿的磷脂肌醇3激酶（PI3K）、内皮素-1（ET-1）含量低于对照组,一氧化氮（NO）含量高于对照组（P〈0.05）;（3）应激反应：观察组患儿的皮质醇、醛固酮以及血糖水平低于对照组（P〈0.05）。结论：右美托咪定有助于稳定生命体征、缓解炎症和应激反应,是小儿七氟醚复合骶管阻滞麻醉后预防苏醒期躁动的理想方法。
Objective： To study the preventive effect dexmedetomidine on emergence agitation of sevoflurane combined with caudal block and its influence on inflammatory stress response. Method： 90 cases received operation below abdomen in our hospital from 2012 March to 2014 June were enrolled and randomly divided into two groups. They were treated with sevoflu- rane combined with sacral block anesthesias observation group was given dexmedetomidine intravenous injection after anesthe- sia induction and control group was given equal dose of saline intravenous injection. Then vital signs, inflammation response and stress response indicators were compared. Results： HR, CI and RPP of observation group were lower than those of control group; P13K, ET-1 contents of observation group were lower than those of control group, NO content was higher than that of control group; cortisol, aldosterone and blood glucose levels of observation group were lower than those of control group. Con- clusion.. Dexmedetomidine contributes to stable vital signs, reduces inflammation and stress responses it＇s an ideal method to prevent emergence agitation after sevoflurane combined with caudal block anesthesia.
出处
《海南医学院学报》
CAS
2015年第5期692-694,698,共4页
Journal of Hainan Medical University
基金
深圳市龙岗区科技创新局(YS2013042)~~
关键词
右美托咪定
苏醒期躁动
七氟醚
炎症
应激
Dexmedetomidine
Emergence agitation
Sevoflurane
Inflammation
Stress
