摘要
目的：分析他汀类药物致横纹肌溶解症患者的用药行为，寻找他汀类药物导致严重不良反应发生的用药危险因素。方法建立患者用药行为的评估方法，从知识、态度、能力三方面评估患者用药行为，以他汀类药物导致严重不良反应的病例为研究对象，临床药师参加现场调查，寻找患者发生不良反应的原因，参与患者严重不良反应的救治。结果近三年有3例他汀类药物致严重不良反应，怀疑药品分别为辛伐他汀和阿托伐他汀，3例患者的用药行为都存在引起不良反应的危险因素。3例患者用药知识得分率均低于20％，不知道药品名称、用量、相互作用、禁用慎用、不良反应；健康态度得分率均低于70％，不会阅读说明书、不知道用药问题的解决方法；服药能力得分率均低于50％，慢性疾病长期用药依从性差。结论药师在严重不良不良反应调查中，发现患者日常用药行为存在风险，是导致患者发生严重不良反应的重要原因。药师要针对患者用药行为风险从知识、态度、能力三方面加强用药教育与宣传，协助患者防范不良反应。
Objective To analyze the behavior of patients with serious adverse drug reactions and look for risk factors leading to serious adverse drug reactions .Methods Patient medication behavior evaluation method was established,which was used in cases of serious adverse reaction caused by stains in recent three years in Beijing Chuiyangliu Hospital .Clinical pharmacists participated in field survey .Medication behavior of patients was analyzed from three aspects of knowledge ,attitude and ability .Results Three patients had serious adverse reactions occurred in recent 3 years,drugs were suspected of simvastatin and atorvastatin .The score of medication knowledge was lower than 20%.The score of health attitude was lower than 20%.The score of taking ability was lower than 20%. Conclusion In the investigation of serious adverse reaction ,pharmacists found the risk behavior of patients with daily medication is an important cause of patients with serious adverse reaction .Pharmacists should strengthen the drug education and publicity ,especially in patients with risk factors of medication behavior such as knowledge ,attitude and ability in their daily work .
出处
《中国基层医药》
CAS
2015年第5期676-678,共3页
Chinese Journal of Primary Medicine and Pharmacy
基金
首都卫生发展科研专项项目（首发2011-7021-02）
关键词
横纹肌溶解
不良反应
危险因素
用药行为
Rhabdomyolysis
Serious adverse drug reaction
Risk factors
Medication behavior
