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单中心脑梗死住院患者病死率及死因分析 被引量:17

Analysis of mortality and cause of death in inpatients with single-center cerebral infarction
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摘要 目的探讨脑梗死住院患者病死率及主要死亡原因。方法回顾性分析2005年1月至2009年12月515例以脑梗死为根本死亡原因的患者的临床资料,计算其住院病死率、直接死亡原因及死因构成比,分析类肝素药物Org10172治疗急性卒中试验(TOAST)分型、年龄、住院病程等临床特点。结果 (1)2005年至2009年每年脑梗死住院患者病死率依次为2.0%(91/4 659)、2.1%(110/5 264)、1.9%(95/5 035)、1.2%(100/8 656)、1.0%(119/11 640),总病死率为1.5%(515/35 254),基本呈逐年下降趋势,差异有统计学意义(χ2=42.39,P〈0.01)。(2)脑梗死住院患者病死率在青年(〈45岁)、中年(45-59岁)、年轻老年(60-74岁)、老年组(〉74岁)分别为1.1%(22/2 009)、1.0%(112/11 158)、1.5%(221/14 311)、2.1%(160/7 776),随年龄增加而增大(P〈0.01)。(3)515例死亡患者TOAST分型依次为:大动脉粥样硬化型57.3%(295例)、心源性栓塞型19.4%(100例)、不明原因型14.4%(74例)、小动脉闭塞型7.0%(36例)、其他原因1.9%(10例)。前5位直接死因:脑疝49.3%(254例)、原发性中枢性呼吸循环衰竭25.0%(129例)、肺炎8.9%(46例)、脑心综合征5.8%(30例)、多器官功能衰竭5.6%(29例)。(4)平均死亡年龄为(67±12)岁,死于脑疝和原发性中枢性呼吸循环衰竭的患者年龄明显小于死于肺炎者[分别为(65±13)、(68±11)、(75±10)岁,均P〈0.01]。住院病程中位数为3.0 d,死于脑疝、原发性中枢性呼吸循环衰竭和脑心综合征的患者住院病程明显短于死于肺炎和多器官功能衰竭患者(住院病程中位数分别为3.0、3.0、3.0、12.5、9.0 d,均P〈0.05)。结论脑梗死住院患者病死率呈逐年下降趋势,脑疾病本身是脑梗死患者早期死亡的最主要原因,提示临床工作中应重点防治。 Objective To investigate the mortality and cause of death in inpatients with cerebral infarction. Methods The clinical data of 515 patients with cerebral infarction as the underlying cause of death from January 2005 to December 2009 were analyzed retrospectively. The hospital mortality, direct cause of death, and constituent ratio of the cause of death were calculated. The clinical features, such as classification of the Trial of Org 10 172 in acute stroke treatment (TOAST) , age and duration of hospital- ization were analyzed. Results ( 1 ) The hospital mortalities in patients with cerebral infarction from 2005 to 2009 were 2. 0% (91/4 659) ,2. 1% (110/5 264), 1.9% (95/5 035 ), 1.2% (100/8 656), and 1.0% ( 119/11 640) , respectively. The overall mortality rate was 1.5 % ( 515/35 254 ) , basically had a declining trend year by year (X2 = 42.39 ;P 〈 0.01 ). (2) The mortalities of the inpatients with cerebral infarction in the young ( 〈 45 years), middle-aged (45 to 59 years), elderly ( 60 to 74 years), and aged (〉74years) groups were 1.1% (22/2 009),1.0% (112/11 158),1.5% (221/14 311),and 2.1% ( 160/7 776) ,respectively. They increased with increasing age ( P 〈 0. 01 ). ( 3 ) The TOAST classification in 515 died patients were as follows :57.3% ( n = 295) for large-artery atherosclerosis, 19.4% (n = 100) for cardioembolism, 14. 4% ( n = 74) for cryptogenic stroke,7. 0% ( n = 36) for small-artery occlusion and 1.9% (n =10) for other reasons. The five leading direct cause of death were cerebral hernia 49. 3% (n = 254) ,primary central respiratory and circulatory failure 25.0% ( n = 129) ,pneumonia 8.9% ( n = 46 ) , cerebral-cardiac syndrome 5.8% ( n = 30), and multiple organ failure 5.6% ( n = 29 ). (4) The mean age of death was 67 ± 12 years old. The patients who died of cerebral hernia and primary central respiratory and circulatory failure were younger than those who died of pneumo
出处 《中国脑血管病杂志》 CAS CSCD 北大核心 2015年第2期62-66,共5页 Chinese Journal of Cerebrovascular Diseases
关键词 脑梗死 病死率 根本死亡原因 直接死亡原因 Brain infarction Case fatality Underlying cause of death Direct cause of death
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