摘要
目的探讨急性脑梗死患者早期CK、CK-MB及cTnI变化及其与预后的关系。方法分别对经颅脑CT/MRI及临床表现确诊的230例急性脑梗死患者,在入院后第1、3、5天进行CK、CK-MB及cTnI动态观测,并对急性脑梗死患者入院及患病后1月时的神经功能缺损进行评分。结果(1)急性脑梗死患者早期CK、CK-MB及cTnI异常的分别有70例、40例和22例。33.04%(76/230)的急性脑梗死患者入院后存在心肌标志物异常;(2)大脑半球梗死的患者CK、CK-MB和cT-nI水平与其它部位脑梗死患者相比有显著性差异(P<0.05);(3)急性脑梗死患者入院时的CK、CK-MB及cTnI水平与神经功能缺损评分呈正相关(P<0.01;P<0.01;P<0.05),而脑梗死患者早期CK-MB及cTnI水平与患病后1月时神经功能缺损评分的差值呈负相关(P<0.05;P<0.01)。结论急性脑梗死患者早期可出现心肌标志物异常,且与脑部梗死部位及预后密切相关。
Objective To explore the early phase alteration of CK, CK--MB and cTnI in patients with acute cerebral infarction and its relationship with prognosis. Methods 230 patients with acute brain infarction confirmed by brain CT/MRI scanning and clinical performance were checked with CK, CK-- MB and cTnI in the 1, 3 and 5th day after hospitalization. Meanwhile, neurological function deficiency of all patients was evaluated at hospitalization and 1 month later. Results （1）There were 70 patients having abnormal CK, 40 patients having abnormal CK--MB and 22 patients having abnormal cTnI respectively in the early phase in 230 patients with cerebral ischemia. 33.04 percent （76/230） patients had abnormal myocardial markings. （2）The level of CK, CK--MB and cTnI in patients with hemisphere infarction had obvious differences comparing to that in patients with other part brain infarction （P 〈 0.05） . （3）There were positive relationship between the level of CK, CK-MB and cTnI and the scores of neuro- logical function deficiency of all patients at hospitalization （P 〈 0.01, P 〈 0.01, P 〈 0.05 respectively）. However, the early phase level of CK--MB and cTnI in acute brain ischemia patients had negative relationship with the scores of neurological function deficiency 1 month after falling ill （ P 〈 0.05;P 〈 0.01 respectively）. Conclusions Patients with acute cerebral ischemia can suffer myocardial markings abnormality in early days. The level of myocardial markings is closely related to location of cerebral infarction and the prognosis of patients.
出处
《神经疾病与精神卫生》
2007年第4期282-284,共3页
Journal of Neuroscience and Mental Health
关键词
脑梗死
心肌标志物
预后
Cerebral infarction
Myocardial marking
Prognosis
