摘要
伴随疾病的进展，机体的代谢标志物随之发生变化，因此，代谢标志物的检测成为疾病早期诊断、治疗以及预后评价的关键。但是，代谢物质的检测，尤其是对大量代谢物质同时检测一直是检验医学难以攻克的难点。代谢组学的出现为检验医学的发展提供了新的契机，尤其是核磁共振波谱技术的新进展和应用，其具有可以在不破坏样本的基础上对大量低丰度的代谢产物进行定量检测的特点和优势。将核磁共振波谱技术与其他方法整合用于标志物的检测，将会有力提高检验医学对于疾病的辅助诊断能力。
Molecular biomarkers could change associated with disease processes. So, the detection of metabolic markers becomes the key to early diagnosis,treatment and prognosis evaluation disease. But the detection of abundant metabolites in body becomes a crux of laboratory medicine at the same time. The recent advances in nuclear magnetic resonance （NMR） spectroscopy reveal the unequivocal value of NMR in metabolomics platforms. NMR spectroscopy has inherently distinct capabilities to identify and quantitatively measure a large amount of low concentration metabolites in a non-destructive manner. The implementation of NMR technology into a multidiseiplinary approach to biomarker identification will improve the auxiliary diagnostic ability of laboratory medicine for the disease.
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2015年第2期88-90,共3页
Chinese Journal of Laboratory Medicine
基金
淮安市科委基金（HAS08010）
关键词
核磁共振波谱
检验
代谢组学
血清
Nuclear magnetic resonance spectroscopy
Laboratory medicine
Metabolomics
