摘要
目的分析55例药物超敏反应综合征的临床表现、实验室检查。方法回顾分析55例药物超敏反应综合征患者的临床资料。结果41例可确定可疑致敏药物，最常见的前三位是抗菌药、解热镇痛药、抗惊厥药。51例患者以皮疹和发热为首发症状，发疹潜伏期为10-42天。其中肝功能损害者48例，血嗜酸粒细胞增多者39例，白细胞升高者24例，肾损害者18例，肺损害者11例，伴浅表淋巴结大者9例。治疗多单独使用糖皮质激素或联合丙种球蛋白。结论药物超敏反应综合征潜伏期长，如在临床用药过程中出现发热、血细胞异常、全身性皮疹和内脏损害者特别是迟发性和长时间的肝功能异常应高度警惕其发生，可使用足量糖皮质激素或联合丙种球蛋白治疗。
Objective To analyze the clinical manifestations and laboratory test. Methods The clinical manifesta- tions, laboratory test results, response to treatment, complications and prognosis of all the 55 patients were analyzed retrospectively. Results In this research ,41 cases could be linked to suspicious sensitizing drugs. The most three common drugs were antimicrobial drugs, antipyretic analgesics, anticonvulsants. Fifty-one patients had rash and fever as the first symptom. The incubation period was 10 - 42 days. Among them, 48 cases had liver damage, 39 cases blood eosinophilia, 24 cases elevated white blood cells, and 18 cases okid- ney damage, 11 cases of lung damage, nine cases with superficial lymph nodes. The majortherapy was using corticosteroids alone or in combination with gamma globulin. Conclusion If patient showed a long incuba- tion period, fever in the clinical course of medication, blood cell abnormalities, generalized rash and damage to internal organs, especially abnormal liver function, DRESS should be considered immediately. Adequate dose of glueocorticoid therapy or in combination with gamma globulin can be used to treat DRESS.
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2015年第3期262-264,共3页
The Chinese Journal of Dermatovenereology
关键词
药物超敏反应综合征
Drug reaction with eosinophilia and systemic symptoms
