摘要
目的:观察蠲痹历节清方治疗湿热蕴结型痛风性关节炎的临床疗效。方法:将符合湿热蕴结证的60例痛风性关节炎患者随机分为两组,对照组采用双氯芬酸钠肠溶片及别嘌呤醇内服治疗,治疗组给予蠲痹历节清方治疗,疗程均为3周。观察治疗前后症状体征变化,并检测血尿酸(UA)、C-反应蛋白(CRP)、白介素-6(IL-6)的变化。结果:治疗组总有效率(93.3%)与对照组总有效率(70.0%)比较,差异有统计学意义(P<0.05)。两组治疗后UA、CRP、IL-6均较治疗前显著降低(P<0.01);治疗后治疗组UA水平低于对照组,差异有统计学意义(P<0.05);两组治疗后CRP水平比较,差异无统计学意义(P>0.05);治疗组IL-6下降值较对照组明显,差异有统计学意义(P<0.05)。结论:蠲痹历节清方治疗湿热蕴结型痛风性关节炎急性发作有较好疗效。
Objective： To observe curative effect of Juanbilijieqing Prescription （蠲痹历节清方） on Damp-heat Syndrome of Gout Arthritis. Methods： The 60 patients with the Damp-heat Syndrome of Gout Arthritis were divided into two groups. Patients were treated with Diclofenac sodium and allopurinol internal in control group, and Juanbilijieqing Prescription in treatment group. The treatment course was 3 weeks. The change of symptoms and signs, serum uric acid （UA）, C-reactive protein （CRP） and in- terleukin （IL-6） -6 were observed. Results： The total effectiveness was 93.3% in treatment group and 70.0% in control group, with significant difference （P〈O.05）; The UA,CRP and IL-6 were significantly lower than before treatment in two groups （P〈0. 01）; after the treatment, the treatment group showed lower UA level than the control group, with statistically significant differ- ence （P〈0.05）; the CRP level differences between the two groups after treatment showed no statistical significance （P〉O.05）; the treatment group showed more apparent decline in IL-6 than the control group, and the difference was statistically significant （P〈 0.05）. Conclusion： Juanbilijieqing Prescription can provide good effect for Damp-heat Syndrome of acute gouty arthritis.
出处
《中医药导报》
2015年第5期23-25,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
湖南省自然科学基金项目(13JJ3102)
关键词
痛风性关节炎
湿热蕴结
蠲痹历节清方
gouty arthritis
Damp-heat Syndrome
Juanbilijieqing Prescription
