摘要
目的探讨三阴性乳腺癌(TNBC)中核因子κB(NF-κB)的表达与临床病理及预后的关系。方法选择2008年1月至2011年12月间191例乳腺癌患者为研究对象,经本院病理科确诊为TNBC 93例,非TNBC 98例。统计NF-κB表达情况,并对NF-κB表达与年龄、肿瘤分期、淋巴结转移、组织学分级、Ki-67表达、肿瘤大小进行相关性分析。结果 TNBC组NF-κB表达阳性率高于非TNBC组,差异有统计学意义(59.14%vs 43.88%,掊2=4.449 1,P=0.034 9)。NF-κB的表达与年龄、肿瘤分期、肿瘤大小差异无统计学意义,但与TNBC淋巴结转移、组织学分级、Ki-67表达情况差异有统计学意义(均P<0.05)。NF-κB阳性患者预后差于阴性患者,差异有统计学意义(掊2=4.592 3,P=0.032 1);NF-κB表达与3年DFS无明显相关。结论 TNBC中NF-κB的表达阳性率高于非TNBC;NF-κB的表达与TNBC淋巴结转移、组织学分级、Ki-67的表达密切相关;NF-κB阳性表明TNBC预后不良。
Objective To explore the expression, pathology and prognosis of nuclear factor kappa B in triple-negative breast cancer. Methods One hundred and ninty-one breast cancer patients diagnosed by the Department of Pathology from January 2008 to December 2011 were chosen as the research objects, with 93 cases of TNBC and 98 cases of non-TNBC. Statistics was carried out for the correlation analysis of the expression of NF-κB with age, tumor stage, lymph node metastasis, histological grading, Ki-67 expression and tumor size. Results Positive rate of NF-κB expression in TNBC group was higher than the non-TNBC group, and the difference was statistically significant （59.14% vs 43.88%, x^2 = 4.449 1, P = 0.034 9）. The expression of NF-κB in TNBC group had no obvious relation to age, tumor stage and tumor size, but it was related to TNBC lymph node metastasis, histological grading, and Ki-67 expression （P 〈 0.05）. TNBC patients with negative NF-κB expression had better prognosis than those with positive expression, which was statistically significant （x^2 = 4.592 3, P = 0.032 1）. NF-κB expression had no sig- nificant correlation with 3-years DFS. Conclusions The expression of NF-κB in TNBC patients is higher than non-TNBC patients. The expression of NF-κB is closely related to lymph node metastasis, histologi- cal grading and Ki-67 expression. Positive NF-κB expression suggests poorer prognosis for TNBC patients. [Key words] Triple-negative breast cancer; Clinical pathology; Prognosis; Nuclear factor kappa B
出处
《中华普通外科学文献（电子版）》
2015年第1期27-29,44,共4页
Chinese Archives of General Surgery(Electronic Edition)
基金
中山市卫生局科研立项(2013J40)
国家留学基金项目(20071059)
关键词
三阴性乳腺癌
临床病理
预后
核因子ΚB
Triple-negative breast cancer
Clinical pathology
Prognosis
Nuclear factor kappa B
