摘要
目的研究依那普利联合氢氯噻嗪治疗原发性高血压的疗效。方法采用回顾性方法分析我院自2013年1月~2014年1月收治的60例原发性高血压患者的临床资料,分为对照组及观察组各30例,两组患者治疗前2周停服其他降压药物,对照组予依那普利,观察组联合应用氢氯噻嗪,连用8周。观察比较两组的疗效及治疗前后SBP及DBP水平变化情况。结果观察组临床总有效率（93.3%）明显高于对照组（70.0%）,两组疗效应用χ2检验处理,差异有统计学意义（P〈0.05）;两组患者治疗后SBP及DBP水平组间比较差异有统计学意义（P〈0.05）,且观察组治疗后的SBP及DBP显著低于对照组。观察组的不良反应发生率明显低于对照组,差异有统计学意义（6.7%vs 20.0%,P〈0.05）。结论依那普利联合氢氯噻嗪治疗原发性高血压疗效优于单一用药,降压效果确切,安全性好,值得推广和应用。
Objective To investigate the effect of enalapril and hydrochlorothiazide in treatment of essential hypertension. Methods The clinical data of 60 patients with essential hypertension were analyzed in our hospital from January2013 to January 2014, and they were divided into observation group and control group, 30 cases in each group, two groups of patients stopped taking other antihypertensive drugs two weeks before treatment, the control group was treated with enalapril, while the observation group was treated with enalapril and hydrochlorothiazide for eight weeks. Changes of SBP and DBP levels before and after treatment and efficacy were compared between the two groups. Results Total effective rate of observation group was 93.3%, the total effective rate of the control group was 70.0%, which was significant higher than the control group（P〈0.05）. After treatment, SBP and DBP levels of two groups had significant differences（P〈0.05）. SBP and DBP levels of observation group were lower than the control group, the occurrence of adverse reactions of observation group were lower than the control group, there was significant difference between the two groups（6.7% vs 20.0%）. Conclusion Enalapril combined with hydrochlorothiazide in treatment of primary hypertension is better than single medication, antihypertensive effect is exact, the security is good, and is worthy of promoting.
出处
《中国现代医生》
2015年第8期84-86,共3页
China Modern Doctor
