摘要
Notch1信号通路是许多细胞信号转导通路的交汇点，不仅在正常组织、细胞的分化、发育过程中起重要作用，而且与一些肿瘤的发生、发展相关，如食管癌、胃癌、宫颈癌、结肠癌、肺癌等。Notch1在非小细胞肺癌中的作用多样。了解Notch1和非小细胞肺癌的关系有利于进一步阐明非小细胞肺癌的发生机制，为非小细胞肺癌的治疗提供一个新的有希望的治疗靶点。
Notchl signal pathway is the intersection point of many cell signal transduction pathways,not only plays an important role in the process of differentiation and development of normal tissue and cell, but also is related to occurrence and development of some tumors, such as esophageal cancer,gastric cancer, cervical cancer, colon cancer, lung cancer, etc. Role of Notch1 in non-small cell lung cancer is diverse. To investigate the relationship between Notch1 and non-small cell lung cancer is conducive to further clarify the pathogenesis of non-small cell lung cancer, and provides a new promising therapeutic target for the treatment of non-small cell lung cancer.
出处
《国际呼吸杂志》
2015年第6期440-444,共5页
International Journal of Respiration
基金
国家自然科学基金资助项目（81172213）
