摘要
目的:观察益气活血中药对急性肺损伤(ALI)机械通气后的肺保护作用。方法:对符合纳入标准67例ALI患者按纳入的时间顺序随机分为2组,对照组32例给予常规综合治疗,观察组35例辅以益气活血中药治疗,60 m L/次,3次/天,连用14天。在服药后第3、7、14天比较患者血气分析、血流动力学、外周血中性粒细胞(PMN)计数指标及支气管镜显像等变化。结果:观察组在PMN、体循环血管阻力(SVR)、心率(HR)、血氧分压(Pa O2)、氧合指数(PO2/Fi O2)及p H值较对照组显著改善(P<0.05)。观察组气管镜下显像提示充血、水肿及炎症反应有显著好转。结论:益气活血中药辅助治疗能改善ALI患者的血流动力学、动脉血气及炎性指标,对肺有较好的保护作用,疗效确切。
Objective： To study the supplementing Qi and activating blood circulation herbs on lung protection in acute lung injury（ ALI） ventilation patients. Methods： 67 cases of ALI patients were enrolled and randomly divided into two groups. Routine treatment was for 32 cases of control group while treatment with adding supplementing Qi and activating blood circulation herbs was for 35 cases of treatment group,by 60 m L per time for 14 consecutive days with each day three times. Hemodynamics,changes of arterial blood gas,assay of pdymorphonuclears（ PMN） value and the image of bronchoscopes between two groups in T0,T3,T7 and T14 were compared. Results： PMN,HR,SVR,Pa O2,PO2/ Fi O2 and pH of treatment group were significantly improved compared with control group during T0,T3,T7 and T14（ P 0. 05）. The compared differences were remarkable on hemodynamics,changes of arterial blood gas and assay of PMN value between treatment group and control group. The image of bronchoscopes in treatment group was improved significantly. Conclusions： The intervention of supplementing Qi and activating blood circulation herbs can effectively protect the lung function from ALI patients who received ventilation.
出处
《中药材》
CAS
CSCD
北大核心
2014年第11期2113-2116,共4页
Journal of Chinese Medicinal Materials
基金
国家自然科学基金青年资助项目(81303131)
关键词
急性肺损伤
机械通气
益气活血
肺保护
Acute lung injury
Ventilation
Supplementing Qi and activating blood circulation
Lung protection
