摘要
目的探讨女性宫外孕术后使用抗生素的效果以及经济学评价,以指导临床合理使用抗生素。方法收集上海市嘉定区中心医院妇产科2007年6月至2014年2月的宫外孕手术患者600例,按照随机数字表法分为抗生素组和非抗生素组,每组300例,抗生素组在术后就开始使用抗生素,非抗生素组术后未使用抗生素,观察两组的效果并且对其进行经济学评价。结果两组宫外孕患者在手术后总的感染率为1.67%,其中抗生素组的感染率为1.33%,非抗生素组的感染率2.00%,两组之间的差别无统计学意义(x^2=0.407,P>0.05)。非抗生素组与抗生素组术后住院天数、术后体温、白细胞及血C反应蛋白差异均无统计学意义(t值分别为1.388、0.818、0.021、0.748、0.538、0.616、5.488,均P>0.05),且术后盆腔感染、伤口愈合不良、月经不正常的发生率差异均无统计学意义(x^2值分别为0.673、0.145、0.202,均P>0.05),而抗生素组的费用显著高于非抗生素组的费用,差异具统计学意义(t=5.488,P<0.05)。结论宫外孕手术后一般不需要使用抗生素,但是当腹腔内出血大于1000mL以及失血过多或中重度贫血给予抗生素治疗。
Objective To study the curative effect of antibiotics after ectopic pregnancy （EP） surgery and economics evaluation, so as to guide reasonable administration of antibiotics in clinics. Methods From June 2007 to February 2014 totally 600 cases with EP surgery were collected from Central Hospital of Jiading District in Shanghai, and they were divided into antibiotics group and non-antibiotics group equally according to random number table method. The antibiotics group began to take antibiotics after surgery, while the non-antibiotics group was not given antibiotics after surgery. The curative effects of two groups were compared and the economic evaluation was done. Results The total infection rate of two groups was 1.67%. The infection rate was 1.33% and 2.00% in the antibiotics group and the non-antibiotics group, respectively, but the difference was not significant （χ^2 = 0. 407 ,P 〉 0.05 ）. There were no statistical differences in days of hospitalization, postoperative body temperature, WBC and serum CRP level between two groups （t value was 1. 388, 0.818, 0. 021, 0.748, 0. 538, 0.616 and 5. 488, respectively, all P 〉 0.05） , and the differences in pelvic infection, poor wound healing and irregular menstruation were not significant （χ^2 value was 0. 673, 0. 145 and 0. 202, respectively, all P 〉 0.05 ）. The cost of the antibiotics group was significantly higher than that of the non-antibiotics group （ t = 5. 488 ,P 〈 0.05 ）. Conclusion Antibiotics is generally not needed after EP surgery. However, antibiotics should be given in the case of abdominal cavity hemorrhage more than 1 000 mL, excessive loss of blood or moderate and severe anemia.
出处
《中国妇幼健康研究》
2015年第1期41-43,共3页
Chinese Journal of Woman and Child Health Research
关键词
宫外孕手术
抗生素
临床效果
经济学评价
ectopic pregnancy surgery
antibiotics
clinical effect
economic evaluation
