摘要
目的初步探讨人微小RNA(miRNA)与埃博拉病毒基因组5'尾标(trailer)序列相互作用,为防治埃博拉病毒提供可能的靶向miRNA。方法运用Pita和RNAhybrid软件预测与埃博拉病毒5'尾标序列相互作用的人miRNA,并对其进行注释和分析。结果与结论发现人miRNA可能与埃博拉病毒5'尾标序列存在复杂的相互作用。根据以前关于宿主miRNA与病毒基因组相互作用的报道,我们认为,人miRNA与埃博拉病毒基因组5'尾标的相互作用可能会影响埃博拉病毒在人体内的复制以及人体细胞的正常功能。该研究将为埃博拉病毒的防治提供新的思考。
Objective To study the interaction between human microRNA（miRNA） and 5＇trailer regions of Ebola virus genome from the perspective of bioinformatics so as to facilitate prevention and treatment of Ebola virus.Method The miRNA target prediction software Pita and RNAhybrid were used to predict the human miRNAs which could bind the 5＇trailer regions of Ebola virus genomes before the miRNAs were annotated by g：Profiler web server.Results and Conclusion There may be complex interactions between human miRNAs and the 5＇trailer regions of Ebola virus.Previous reports about the interaction between host miRNA and 5＇trailer region of virus genome suggest that the interaction between human miRNA and 5＇trailer region of Ebola virus may have effect on replication of Ebola virus and human cells.This work may provide new ideas on prevention and treatment of Ebola virus.
出处
《军事医学》
CAS
CSCD
北大核心
2015年第1期6-11,共6页
Military Medical Sciences
基金
国家自然科学基金资助项目(31271404
31300093
31471244)
