摘要
包括新型冠状病毒(SARS-CoV-2)在内的呼吸道病毒为世界公共卫生及人类的生命安全带来巨大威胁。呼吸道病毒易感染、易变异、易流行和跨物种传播的特点为传统抗病毒药物及疫苗的研发提出挑战,安全有效的广谱抗病毒药物研发势在必行。中药多成分、多靶点、多途径的作用特点使其在抗呼吸道病毒新药开发方面具有极大的优势和潜力。本文在分析广谱抗呼吸道病毒药物研发现状的基础上,总结了中药在治疗临床常见的多重病毒感染、应对病毒变异和耐药性以及免疫调节和整体治疗上的独特价值,探讨了基于呼吸道病毒共性靶点、某类病毒靶点拓展、靶点的收敛与优化、核心病机的大数据组方筛选的广谱抗呼吸道病毒中药发现路径,为中医药抗病毒新药研发和应对呼吸道病毒传染病提供新的策略。
Respiratory viruses including SARS-COV-2 have posed great threats to world public health and human life safety. Respiratory viruses are easy to infect, mutate, spread across species, which were challenges for traditional antiviral drugs and research and development of vaccine. It is imperative to develop broad-spectrum antiviral drugs that are safe and effective. Traditional Chinese medicines are characteristic of multi-component, multi-target and multi-pathway, making them have great advantages and potential in the development of new drugs against respiratory viruses. Based on the analysis on the current research and development status of broad-spectrum antiviral drugs, this paper summarizes the traditional Chinese medicines regarding their unique values in treatment of multiple viral infections, their responses to virus mutation and drug resistance, immune regulation and overall treatment. We also discuss the approaches of Chinese herbal medicine R&D against broad-spectrum respiratory viruses, including exploring the common targets, expanding certain kind of virus targets, targets convergence and optimization, the big data-based core pathogenesis screening, which provide new strategies for research and development of such traditional Chinese medicine and dealing with respiratory virus infection.
作者
李兵
张洪春
杨子峰
段大跃
刘骏
王忠
王永炎
LI Bing;ZHANG Hong-chun;YANG Zi-feng;DUAN Da-yue;LIU Jun;WANG Zhong;WANG Yong-yan(Instiute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;China-Japan Friendship Hospital,Bejing 100029,China;Guangzhou Institute of Respiratory Health,Guangzhou 510180,China;Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University,Luzhou 646699,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2022年第1期33-38,共6页
Chinese Journal of New Drugs
基金
国家“重大新药创制”科技重大专项资助项目(2017ZX09031059)
国家自然科学基金资助项目(81803966)
中国中医科学院基本科研业务费自主选题(Z0607)。
关键词
呼吸道病毒
广谱抗病毒
中药研发
抗病毒中药
新型冠状病毒
respiratory virus
broad-spectrum antivirus
Chinese herbal medicine research and development
antiviral Chinese herbal medicine
SARS-CoV-2
