摘要
目的：检测膜联蛋白 A2（ANXA2）和波形蛋白（Vimentin）在子宫腺肌病（AM）患者在位及异位内膜中的表达情况，探讨二者在子宫腺肌病发生、发展中的作用及相互关系。方法采用免疫组化 SP 法检测35例AM患者的异位内膜、在位内膜及20例子宫肌瘤患者的正常子宫内膜中 ANXA2和 Vimentin 的表达情况。结果ANXA2和 Vimentin 在正常子宫内膜（15．0％和20．0％）、AM在位内膜（51．4％和57．1％）和异位内膜（82．9％和85．7％）中的阳性表达率均呈上升趋势，且二者在 AM的增生期与分泌期的表达情况不同；ANXA2和 Vimentin 在AM异位内膜增生期（92．0％和96．0％）及在位内膜中增生期（64．0％和72．0％）的阳性表达率均高于分泌期；ANXA2和 Vimentin 在子宫腺肌病中的表达呈正相关（rs ＝0．298）。结论 ANXA2和 Vimentin 在子宫腺肌病中的高表达，二者可能参与其发生、发展，且表达强度与患者处于月经周期的不同分期有关，增生期的阳性表达率均高于分泌期；ANXA2和 Vimentin 在子宫腺肌病中的表达呈正相关，可协同促进其发生、发展。
Objective To examine the expression of ANXA2 and vimentin in ectopic and eutopic endometrial tissues in patients with adenomyosis in order to explore their role in the pathogenesis of adenomyosis. Methods The expression of ANXA2 and vimentin in ectopic and eutopic endometrial tissues of 35 patients with adenomyosis and in normal endometrial tissues of 20 patients with hysteromyoma was assayed by the use of immunohistochemistry. Results The positive rates of ANXA2 and vimentin in normal,eutopic,and ectopic endometrium showed a gradual increase.Differences were observed in the expression of ANXA2 and vimentin between the proliferative phase and the secretory phase.Further analysis showed that the expression of ANXA2 and vimentin was positively correlated. Conclusion Overexpression of ANXA2 and vimentin may be associated with the development of adenomyosis.The expression of ANXA2 and vimentin was correlated with stage of menstrual cycle,with higher expression in proliferative phase than in secretory phase.The expression of ANXA2 and vimentin was positively correlated in adenomyosis,suggesting that they may promote the development of adenomyosis.
出处
《中国生育健康杂志》
2015年第2期128-132,共5页
Chinese Journal of Reproductive Health
