摘要
目的:观察局部热疗联合化疗治疗晚期胰腺癌的疗效。方法:2008年5月至2010年8月于我院就诊的61例晚期胰腺癌患者,简单随机分为治疗组31例和对照组30例。对照组采用吉西他滨和顺铂联合化疗。治疗组在对照组的基础上联合局部区域热疗。观察两组患者在3个月、6个月、9个月、12个月、18个月的生存率、临床疗效、临床受益反应及不良反应。结果:两组患者在3个月、6个月、9个月、12个月、18个月的生存率比较,差异不明显,均无明显统计学意义(P>0.05)。所有患者治疗后症状均有所缓解,治疗组有效率(RR)为41.94%,而对照组为16.67%(P=0.0305)。治疗组疾病控制率(DCR)为77.42%,而对照组为50.00%(P=0.0258)。治疗组CBR有效率为54.84%(17/31),对照组为30.00%(9/30)(P=0.0499)。不良反应包括胃肠毒性、肝功能异常、肾功能异常及血液毒性,但两组各项不良反应发生率大致相当,差异均无明显统计学意义(P>0.05)。结论:局部热疗联合化疗治疗晚期胰腺癌时能够明显缓解患者的症状,提高有效率和疾病控制率,也有效提高患者的临床受益反应有效率,且不影响患者的生存率及治疗后未增加患者的不良反应。
Objective：To analyze the clinical efficacy of local hyperthermia in the treatment of advanced pancreat-ic cancer. Methods：All 61 patients with advanced pancreatic cancer were selected and randomly divided into the treatment group 31 patients and control group 30 patients. Patients in the control group were treated with gemcitabine and cisplatin combination chemotherapy,while the treatment group combined local hyperthermia. Observed the surviv-al rates at 3 months,6 months,9 months,12 months,18 months,clinical efficacy,clinical benefit response and adverse reactions. Results：The survival rates of two groups of patients at 3 months,6 months,9 months,12 months,18 months,were no significant difference（P 〉 0. 05）. After treatment,all patients symptoms were alleviated,the efficien-cy rate of the treatment was 41. 94% ,while that of the control group was 16. 67%（P = 0. 0305）,disease control rate （DCR）of the treatment was 77. 42% ,while that of the control group was 50. 00% ,the difference was also statistical-ly significant（P = 0. 0258）. CBR of the treatment group was 54. 84%（17 ∕ 31）,while that of the control group was 30. 00%（9 ∕ 30）,the difference was statistically significant（P = 0. 0499）. The main adverse reactions,including gas-trointestinal toxicity,abnormal liver function,renal dysfunction and blood toxicity. However,the incidence of adverse reactions of the two groups were roughly the same,the difference was not statistically significant（P 〉 0. 05）. Conclu-sion：Local hyperthermia in the treatment of advanced pancreatic auxiliary can significantly alleviate the symptoms and improve the efficiency and disease control rate,and improve the patientˊs clinical response efficiency,does not affect the survival rate,does not increase adverse reactions.
出处
《现代肿瘤医学》
CAS
2015年第5期655-657,共3页
Journal of Modern Oncology
基金
荆门市卫生局立项课题(编号:20120342)
关键词
局部热疗
化疗
晚期胰腺癌
local hyperthermia
chemotherapy
advanced pancreatic cancer
