摘要
目的 探讨孟鲁司特在小儿呼吸道合胞病毒毛细支气管炎治疗中的应用效果.方法 以2013年2月到2014年1月我院收治的86例呼吸道合胞病毒毛细支气管炎患儿为研究对象,随机分为两组,分别进行孟鲁司特治疗（治疗组）和常规综合性治疗（对照组）.比较两组临床疗效、喘息缓解时间、住院时间、咳嗽、啰音、喘憋、鸣音等症状消失时间、半胱氨酰白三烯（CysLTs）、嗜酸性粒细胞阳离子蛋白（ECP）变化及复发情况.结果 治疗组总有效率为95.35％,对照组总有效率为74.42％.两组临床疗效比较,差异具有统计学意义（P＜0.05）.治疗组喘息缓解时间、住院时间、症状消失时间均明显低于对照组,差异具有统计学意义（P＜0.05）.治疗前,两组CysLTs、ECP无明显差异,不具有统计学意义（P＞0.05）.治疗后,治疗组CysLTs、ECP均明显低于对照组（P＜0.05）.治疗组复发3例（6.98％）,对照组复发12例（27.91％）,差异具有统计学意义（P＜0.05）.结论 孟鲁司特治疗小儿RSV毛细支气管炎疗效确切、安全可靠,具有起效快、并发症少的特点,值得临床推广 .
Objective To investigate the clinical effect of montelukast in children with respiratory syncytial virus bronchiolitis.Methods February 2013 to January 2014 in our hospital,86 patients of respiratory syncytial virus bronchiolitis were randomly divided into two groups,montelukast therapy （treatment group） and conventional comprehensive treatment （control group）.Clinical effect,respite relief time,hospital stay,cough,rales,wheezing,and other symptoms disappeared beep time,cysteinyl leukotrienes （CysLTs）,eosinophil cationic protein （ECP） and change recurrence were compared and analyzed.Results The total effective rate of the treatment group was 95.35% and the total effective rate of the control group was 74.42%.There was statistically difference comparison of the clinical efficacy of the two groups （P 〈 0.05）.The respite relief time,hospital stay time,symptoms disappear time of the treatment group were significantly lower than that of the control group.Before treatment,CysLTs and ECP of the two groups had no significant difference （P 〉 0.05）,but there was statistically difference after treatment （P 〈0.05）.Relapsed three cases of treatment group （6.98%）,12 cases of recurrence in the control group （27.91%） and there was statistically difference （P 〈0.05）.Conclusions Montelukast treatment for pediatric RSV bronchiolitis is a effective,safe and reliable treatment options with rapid onset,fewer complications,which is worthy of promotion.
出处
《国际病毒学杂志》
2015年第1期48-51,共4页
International Journal of Virology
关键词
孟鲁司特
呼吸道合胞病毒
毛细支气管炎
喘息
疗效
Montelukast
Respiratory syncytial virus
Bronchiolitis
Wheezing
Clinical effect
