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低分子量肝素钠对胃肠道肿瘤术后静脉血栓栓塞症预防的安全性和有效性临床观察 被引量:1

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摘要 目的探讨低分子量肝素钠对胃肠道肿瘤术后静脉血栓栓塞症预防的安全性和有效性。方法选取该院收治的胃肠道肿瘤术后静脉血栓栓塞症高危患者56例进行分析,按照随机数字表法分成观察组和对照组两组,每组28例,两组均皮下注射低分子肝素钠,观察组24 h/次,对照组12 h/次,观察两组术后72 h引流液、术后7 d血浆D-二聚体含量和抗-Xa活性以及出血并发症发生率。结果两组在术后72 h引流液和术后7 d血浆D-二聚体含量上差异无统计学意义(P>0.05),两组在术后1 d、3 d、7 d抗-Xa活性上比较差异无统计学意义(P>0.05),观察组出血并发症发生率明显低于对照组(P<0.05)。结论两种用药方案均能够达到有效抗凝强度,随着用药的延长均能够有效预防胃肠道肿瘤术后静脉血栓栓塞症,但是皮下注射12 h/次会增加出血并发症的风险。
作者 郎建华
出处 《中外医疗》 2014年第16期117-118,共2页 China & Foreign Medical Treatment
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