摘要
目的评估5-氨基酮戊酸光动力学疗法(5-ALA-PDT)治疗老年糖尿病患者的念珠菌性间擦疹的疗效。方法将老年糖尿病念珠菌性间擦疹患者40例随机分为治疗组和对照组,以氦氖激光为激发光源﹑ALA为光敏剂﹑使用DMSO作为ALA的溶剂兼穿透增强剂,对治疗组进行5-ALA-PDT治疗;对照组给予外用特比萘芬乳膏治疗。观察比较两组治疗后临床治愈率。结果完成治疗后0个月、1个月、2个月、3个月,治疗组的治愈率分别为100%、75.0%、50.0%、15.0%。对照组的治愈率分别为90.0%、80.0%、65.0%、30.0%。两组各时间点的治愈率无明显差异(P均>0.05)。结论 5-ALA-PDT能在短期内有效地治疗老年糖尿病患者的念珠菌性间擦疹,但很快复发。
Objective To evaluate the efficacy of 5-aminolevulinic acid photodynamic therapy in treatment of candidal intertrigoes in elderly patients with diabetes mellitus. Methods Forty elderly patients with diabetes mellitus associated with candidal intertrigoes were randomly divided into experimental group and control group. The application of He- Ne laser as the excitation source,ALA as photosensitizer,DMSO as penetration enhancer and solvent,ALA- PDT had been done in patients of experimental group. Patients in control group were given with topical application of terbinafine hydrochloride cream. Results The curative rates of experimental group were 100%,75. 0%,50. 0% and 15. 0% at the time points of 0 month,1 month,2 months and 3 months respectively after performance of 5- ALA- PDT. Meanwhile the curative rates of control group were 90. 0%,80. 0%,65. 0% and 30. 0% at the time points respectively. There was no significant difference in curative rate between these 2 groups. Conclusion 5- ALA- PDT can effectively cure candidal intertrigoes in elderly patients with diabetes mellitus in a shorter period. However,recurrence of candidal intertrigoes is quick.
出处
《临床和实验医学杂志》
2014年第18期1503-1505,共3页
Journal of Clinical and Experimental Medicine
基金
广西卫生厅课题(编号:Z2012552)
