摘要
目的 观察阿托伐他汀对心肌梗死后大鼠基质金属蛋白酶（MMP）-2、微小RNA（miRNA,miR）-21表达的影响.方法 选取140只Wistar大鼠建立急性心肌梗死模型,分为假手术组、对照组、阿托伐他汀低剂量组和高剂量组,进行左室重量指数、心肌胶原容积分数、miRNA-21及MMP-2 mRNA表达测定.结果 阿托伐他汀治疗组左室重量指数、心肌胶原容积分数、梗死周边区miR-21 、MMP-2 mRNA的表达均降低（P＜0.05）;各组梗死周边区miR-21表达量与MMP-2 mRNA水平呈正相关（r对照组=0.611,P＜0.05;r阿托伐他汀低剂量组=0.502,P＜0.05;r阿托伐他汀低剂量组=0.541,P＜0.05）.结论 阿托伐他汀能降低梗死周边区MMP-2和miR-21的表达,发挥减轻心室重构的作用.
Objective To explore the effects of atorvastatin on the matrix metalloproteinase （MMP）-2 and microRNA （miRNA,miR）-21 expression in rats with myocardial infarction.Methods The models of acute myocardial infarction were established in 140 Wistar rats.All rats were divided into sham operation group,myocardial infarction control group,low atorvastatin group and high atorvastatin group.Left ventricular mass index （LVMI）,collagen volume fraction （CVF）,MMP-2 and miR-21 were detected after operation.Results LVMI,CVF,and the expression of miR-21 and MMP-2 mRNA were significantly decreased in atorvastatin groups （P 〈 0.05） ; The expression of miR-21 and MMP-2 mRNA in the surrounding infarct areas had a positive correlation （rcontrol group =0.611,P〈 0.05;r low atorvastatin group =0.502,P〈0.05; rhigh atorvastatin group =0.541,P〈0.05）.Conclusion Atorvastatin could decrease the level of MMP-2 and the expression of miR-21 in rats with myocardial infarction,which could improve ventricular remodeling and heart function.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2015年第2期374-376,共3页
Chinese Journal of Experimental Surgery
