摘要
目的分析在脑梗死患者治疗中早期应用他汀类药物的治疗价值。方法随机选取枣庄市中医医院收治的脑梗死患者150例,均为2019年1月—2021年12月收治,随机均分为对照组与观察组,对照组进行常规治疗,观察组在对照组基础上加用他汀类药物进行早期治疗,比较两组患者的治疗总有效率、血脂水平变化、血清超敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)与同型半胱氨酸(homocysteine,Hcy)水平变化、脑血流指标水平变化及治疗后的自理能力恢复情况。结果观察组治疗总有效率(97.33%)高于对照组(85.33%),比较差异有统计学意义(P<0.05);治疗前,两组总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density liptein cholesterol,LDL-C)水平比较差异无统计学意义(P>0.05),治疗后,观察组TC、TG、LDL-C水平均低于对照组,HDL-C水平高于对照组,比较差异均有统计学意义(P<0.05);治疗前,两组血清hs-CRP、Hcy水平均较高,但比较差异无统计学意义(P>0.05),治疗后,观察组血清hs-CRP、Hcy水平均低于对照组,比较差异均有统计学意义(P<0.05);观察组的依赖程度显著低于对照组,其中观察组独立率高于对照组,比较差异有统计学意义(P<0.05);观察组轻度依赖率高于对照组,中度依赖率、重度依赖率观察组低于对照组,但比较差异无统计学意义(P>0.05);治疗前,两组平均血流速度(mean velocity,Vm)、阻力指数(resistance index,RI)、脉动指数(pulsatility index,PI)及收缩期血流速度(systolic velocity,Vs)比较差异均无统计学意义(P>0.05),治疗后,观察组Vm、Vs均高于对照组,RI、PI均低于对照组,比较差异均有统计学意义(P<0.05)。结论在脑梗死患者治疗中通过早期应用他汀类药物能够显著提升治疗效果,帮助调节血清血脂水平,改善炎症性反应,且有助于提高患者的生
Objective To analyze the therapeutic value of early application of statins in patients with cerebral infarction.Methods A total of 150 patients with cerebral infarction admitted to Zaozhuang Hospital of Traditional Chinese Medicine from January 2019 to December 2021 were randomly selected and divided into the control group and the observation group.The control group received routine treatment,while the observation group received early treatment with statins on the basis of the control group,and the total effective rate of treatment,changes in blood lipid levels,changes of serum high sensitivity C-reactive protein(hs-CRP)and homocysteine(Hcy)levels,changes of cerebral blood flow indicators and the recovery of selfcare ability after treatment were compared between the two groups.Results The total effective rate of the observation group(97.33%)was higher than that of the control group(85.33%),with a statistically significant difference(P<0.05).Before treatment,the levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)in the two groups had no significant difference(P>0.05).After treatment,the levels of TC,TG and LDL-C in the observation group were lower than those in the control group,and the level of HDL-C was higher than that in the control group,the differences were statistically significant(P<0.05).Before treatment,the levels of hs-CRP and Hcy in serum of the two groups were high,but there was no significant difference(P>0.05).After treatment,the levels of hs-CRP and Hcy in serum of the observation group were lower than those of the control group,and there were significant difference(P<0.05).The dependence degree of the observation group was significantly lower than that of the control group,and the independence rate of the observation group was higher than that of the control group,with significant difference between groups(P<0.05).In addition,the mild dependence rate in the observation group was higher than that in the control g
作者
苗润新
MIAO Runxin(Department of Emergency,Zaozhuang Hospital of Traditional Chinese Medicine,Zaozhuang Shandong 277000,China)
出处
《中国卫生标准管理》
2022年第18期130-134,共5页
China Health Standard Management
关键词
脑梗死
他汀类药物
早期
自理能力
血脂
炎症反应
价值
cerebral infarction
statins
early
self-care ability
blood lipid
inflammatory response
value
