摘要
目的评价红外激光联合α-硫辛酸辅助治疗糖尿病周围神经病变(DNP)的临床疗效。方法 106例DPN患者随机分为观察组和对照组,各53例,对照组给予糖尿病基础治疗,静脉滴注α-硫辛酸注射液0.6 g,每日1次;观察组在此基础上加用红外激光治疗,2组疗程均为12 d。观察2组患者治疗前后临床症状的改善情况、定性温度觉,同时监测其神经传导速度。结果治疗后,观察组显效率和总有效率分别为52.83%和90.57%,显著优于对照组的41.51%和86.66%(P<0.05)。治疗后,2组腓总神经和腓肠神经传导速度比治疗前均明显增加(P<0.05)。2组均无明显药品不良反应发生。结论红外激光联合α-硫辛酸治疗糖尿病周围神经病变能显著改善患者症状和神经传导速度。
Objective To observe the clinical efficacy of infrared laser combined with alpha- zinc sulfate for the treatment of diabetic peripheral neuropathy（ DNP）. Methods A total of 106 patients with DPN were randomly divided into observation group（ n = 53） and control group（ n = 53）. Besides base hypoglycemic drug therapy,patients in the control group received alpha- zinc sulfate injection 0. 6 g once a day.The patients in observation group were given the above treatment plus anodyne therapeutic apparatus treatment. The treatment period lasted for12 days. The data of clinical symptoms,temperature,and nerve conduction velocity of two groups were observed before and after treatment.Results The effective rate and total effective rate were 52. 83% and90. 57% in the observation group,significantly better than 41. 51% and86. 66% in control group（ P〈0. 05）. The data of peroneal nerve and sural nerve conduction velocity in observation group were much significantly improved than before treatment（ P〈0. 05）. No significant adverse effect was observed. Conclusion Infrared laser combined with alpha-zinc sulfate is effective on the treatment of diabetic peripheral neuropathy.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第3期166-168,共3页
The Chinese Journal of Clinical Pharmacology
