摘要
目的研究乳头状甲状腺癌中KISS-1、VEGF-C的表达及与临床病理的关系。方法选取2012年7月到2013年7月我院收集的乳头状甲状腺癌病理标本60例(研究组),另选取正常甲状腺组织30例(对照组),应用免疫组织化学SP法测定KISS-1、VEGF-C在两组中的表达情况,并分析其与临床病理的关系。结果研究组KISS-1阳性者显著少于对照组,VEGF-C阳性者显著多于对照组,两组比较差异具有统计学意义(P<0.05);KISS-1、VEGF-C在乳头状甲状腺癌组织的表达和肿瘤大小、临床分期以及颈部淋巴结转移有关,且差异具有统计学意义(P<0.05),KISS-1、VEGF-C的表达和年龄、性别无关,差异无统计学意义(P>0.05)。结论 KISS-1、VEGF-C的表达和乳头状甲状腺癌存在一定关系,且和肿瘤的大小、临床分期以及颈部淋巴结转移有关。
Objective To study the expression and relationship with clinical pathology of KISS-1,VEGF-C in papillary thyroid carcinoma.Methods 60cases（the study group）pathological specimens of papillary thyroid carcinoma were collected from our hospital during the period from July 2012 to July 2013,30cases（the control group）normal thyroid tissue were also collected,the expression of two groups of KISS-1,VEGF-C were measured in immunohistochemical SP method,and to analyze its relationship with clinical pathology.Results The KISS-1positive of the study group were significantly less than the control group,VEGF-C positive of the study group were significantly more than the control group,the difference was statistically significant（P〈0.05）;the expression of KISS-1,VEGF-C in papillary thyroid carcinoma had relationship with tumor size,clinical stage and lymph node metastasis,the difference was statistically significant（P〈0.05）,the expression of KISS-1,VEGF-C had no relationship with age and sex,the difference was no statistically significant（P〉0.05）.Conclusion The expression of KISS-1,VEGF-C had relationship with papillary thyroid carcinoma,and had relationship with tumor size,clinical stage and lymph node metastasis.
出处
《中国实验诊断学》
2015年第2期223-225,共3页
Chinese Journal of Laboratory Diagnosis
