摘要
目的:探讨环氧合酶-2(COX-2)与甲状腺肿瘤血管生成的关系,研究COX-2和血管内皮生长因子(VEGF)在甲状腺癌中的表达及临床意义。方法:应用免疫组织化学方法检测60例甲状腺癌、15例甲状腺腺瘤及10例正常甲状腺组织中COX-2和VEGF的表达,并对甲状腺癌组织学分型、临床病理分期及淋巴结转移进行对比分析。结果:COX-2和VEGF在甲状腺癌中的表达明显高于甲状腺腺瘤(P<0.01),正常甲状腺组织未见表达;甲状腺癌中COX-2与VEGF的表达呈正相关(r=0.636,P<0.01)。二者表达均与甲状腺癌组织学分型、临床病理分期及淋巴结转移有关(P<0.05)。结论:COX-2和VEGF在甲状腺癌中呈高表达。COX-2可能通过多种途径促进甲状腺癌的发生和发展;COX-2对VEGF的高表达可能具有潜在的正向调控作用,进而影响甲状腺癌的浸润和转移。
Objective To investigate the relationships between Cyclooxygenase （COX-2） and angiogenesis and expressions of COX-2 and vascular endothelial growth factor （VEGF） in thyroid cancer and its clinical significance. Methods Immunohistochemistry was used to detect the expressions of COX-2 and VEGF in 60 thyroid cancer, 15 thyroidadenomas and 10 normal thyroid tissues. Results The expression rates of COX-2 and VEGF in thyroid cancer were higher than those in thyroid adenomas and normal tissues （P〈0.01）. The expressions of COX-2 and VEGF in thyroid cancer presented positive correlation （r=0. 636, P〈0.01）. The expression rates of COX-2 in thyroid papillary cancer and undifferentiated cancer were 47.1% and 90.0% . The expression rates of VEGF in thyroid papillary cancer and undifferentiated cancer were 71.4% and 100% The expression rates of COX-2 and VEGF in TNM Ⅰ and Ⅱ were lower than those in TNM ill and IV （P〈0.05）. The expression rates of COX-2 and VEGF in thyroid cancer with lymph node metastasis were higher those that without lymph node metastasis （P〈0.05）. Oonclusion COX-2 and VEGF express highly in thyroid cancer. The expressions of COX-2 and VEGF in thyroid cancer correlates with pathological type, TNM phase and lymph node metastasis of thyroid cancer.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2006年第6期1077-1080,F0003,共5页
Journal of Jilin University：Medicine Edition
基金
吉林省科技厅国际合作项目资助课题(20050207)
